Welcome to The Lab, FiveThirtyEight’s basketball podcast. On this week’s show (Jan. 11, 2018), LaVar Ball has been making headlines for calling out Lakers head coach Luke Walton, saying the players “don’t want to play for him.” Neil, Chris and Kyle break down the stats to see if these claims hold any merit. Next, the Minnesota Timberwolves are having an impressive season, perhaps even impressive enough to contend for the Western Conference championship. Who’s responsible for their season’s turnaround? We investigate. Plus, a small-sample-size segment on Steph Curry’s incredible numbers of late.Here are links to what was discussed this week:Keep an eye on our 2017-18 NBA predictions, updated after every game.Lonzo Ball and Luke Walton responded to LaVar’s comments.The Ringer took a look at the Timberwolves and Jimmy Butler’s rise.Wednesday night, Steph Curry was out again with an ankle injury. Embed Code By Neil Paine, Chris Herring and Kyle Wagner More: Apple Podcasts | ESPN App | RSS | Embed
Facebook Twitter Google+LinkedInPinterestWhatsAppTurks and Caicos, April 19, 2017 – Providenciales – An alleged criminal couple was arrested by Police and charged with aggravated burglary and robbery. A 36 year old woman and her 30 year old husband are the TCIs own ‘Bonnie and Clyde’ it appears as Police say in a report that the duo was caught with stolen goods and are their suspects in the case where a resident of Belgrade Gardens was pistol whipped and robbed of a Jamaican passport and his 2008 Nissan Skyline sedan. The home invasion is from April 7, 2017 and led to the man being hospitalized with injuries.#MagneticMediaNews#husbandandwifearrestedinTCI#TCIBonnieandClyde Related Items:#husbandandwifearrestedinTCI, #magneticmedianews, #TCIBonnieandClyde Facebook Twitter Google+LinkedInPinterestWhatsApp
Facebook Twitter Google+LinkedInPinterestWhatsApp#TurksandCaicos, October 25, 2017 – Providenciales – The Young Corporate Alliance is breaking ground in the Turks and Caicos and is expanding its support to younger business professionals and business owners between 18 and 40 with a BlackCard offer for significant savings and discounts among key companies which are signed onto the program.The Corporate Black Card was unveiled yesterday and executives of YCA, which was established in 2015 say, eleven companies are on board. Up to 75% discount for some services from law firms in the program and those include TWA MarcelinWolf, StanbrookLaw and Savory&Co; there are marketing and media companies like OutsideoftheBox Marketing, CayaHicoMedia, Island Printing and RogerHarvey&Co. Business services and supplies firms are on board like Business Solutions, Digicel, NW Hamilton and HLB.The Corporate Black Card of the YCA is for its Platinum membership tier only and President Dominic Rolle led a team which also explained that applying can happen at their website, the card is valid for one year and an Executive Board is established to oversee compliance related to the card. The card is black and prominently features the YCA logo and the title Black Corporate Card in an elegantly sophisticated design. The launch was called a pioneering positive step for the Turks and Caicos economy.#MagneticMediaNews#YoungCorporateAlliance#YCABlackCard Recommended for you Facebook Twitter Google+LinkedInPinterestWhatsApp Related Items:#magneticmedianews, #YCABlackCard, #youngcorporatealliance Young Business Leaders Travel to the Netherlands For Providenciales Incubator
Sasha Foo, January 18, 2018 Categories: Local San Diego News Tags: San Diego State University, SoccerCity FacebookTwitter Backers of ‘SoccerCity’ development tout benefits to taxpayers and San Diego State Sasha Foo San Diego voters will get the chance in November to decide between two development plans for the Mission Valley site that was once Qualcomm Stadium.On Tuesday, supporters of the proposal to expand San Diego State turned in their signatures, as part of the process to qualify their plan as a voter initiative.Not to be eclipsed, proponents of the rival “SoccerCity” plan produced more arguments today to support their measure.KUSI’S Sasha Foo has the story. Posted: January 18, 2018
FacebookTwitter Posted: March 18, 2018 KUSI Newsroom SAN DIEGO (KUSI) – A 63-year-old man remained hospitalized today following a stabbing in Sherman Heights.The injury was inflicted at about 8:30 p.m. Saturday in the 2200 block of Imperial Avenue.The victim was arguing with a 19-year-old man, according to Officer Robert Heims of the San Diego Police Department. During the argument, the latter is suspected of stabbing the former once in the left rib cage below the armpit, Heims said.The suspect then fled in an unknown direction. He was described as Hispanic, about 5 feet-8 inches tall, thin and wearing a brown jacket and gray hoodie.The victim was taken to a hospital with non-life-threatening injuries, Heims said. Man injured in Sherman Heights stabbing KUSI Newsroom, Categories: Local San Diego News Tags: Crime, sherman heights, stabbing March 18, 2018
Gersh is also expected to join the board of directors in the “near future”. In addition to Gersh’s hire, Blackstone Advisory Partners have been retained to “review and respond” to companies interested in investing and/or partnering with MSLO, as well as “exploring other opportunities”, according to a company release. Of this decision, Martha Stewart says, “As the founder and largest stockholder, I fully support this initiative to take our business and iconic brand to the next level.” In 2009, Wenda Harris Millard stepped down from her role as co-CEO, where she worked in tandem with Robin Marino. Until Gersh, there was no replacement named. Lisa Gersh has been tapped as president and chief operating officer of Martha Stewart Living Omnimedia (MSLO), effective June 6.Gersh will report to Charles Koppelman, executive chairman and principal executive officer, and will be in charge of day-to-day business operations. A succession plan has also been put in place, with Gersh being integrated into the company and set to become CEO within 12-20 months of her hire. MSLO also announced today that Martha Stewart herself is slated to rejoin the board of directors in the third quarter of 2011. After being convicted in 2004 and a settlement of charges with the Securities and Exchange Commission in 2006, Stewart was barred from being a director or officer in the public company for five years. In other MSLO news, Patsy Pollack has been named senior executive vice president, in charge of lead merchandising business, succeeding Marino. Pollack has been with the company since 2008; before this, she was CEO of Donna Karan Home. In the first quarter of 2011, MSLO publishing revenue was up to $34.66 million from $31.36 in the first quarter of 2010. However, broadcasting fell for to $7.76 million in first quarter 2011 from $12.09 million in first quarter 2010.Update – On May 25, the day Gersh’s hire was announced, MSLO stock was up by 90 cents (+23 percent) to $4.67 per share. Currently, MSLO stock is down 1.5 percent, at $4.60 per share.
Union Finance Minister Arun Jaitley’s personal wealth declined by Rs. 6 crore to Rs. 60.99 crore in the financial year 2016, said data released by the government. It was Rs. 67.01 crore in FY2015. The other ministers are yet to file their financial assets for the year.Jaitley’s financial details included both his movable and immovable assets. The decline in wealth was mainly on account of reduction in his bank balance and number of vehicles owned.Movable AssetsThe minister’s liquidity, under three savings accounts at HDFC Bank and another at SBI, were reduced collectively by Rs. 2.52 crore to Rs.1 crore in 2016. Jaitley’s cash in hand too fell by Rs. 30 lakh to Rs. 65.29 lakh in the same fiscal. The total value of his four cars â€“ two Mercedes, a Toyota Fortuner and a Honda Accord â€“ in FY2016 was Rs. 1.93 crore; lesser by Rs. 86 lakh worth BMW he owned in 2015.His movable assets such as loans and advances stood Rs. 20 lakh more at Rs. 9.34 crore in FY2016. He had also given out more advances for properties worth Rs. 75.6 lakh this year (2016).Jaitley owned gold (5.6 kg), silver (15 kg) and diamonds, which were worth Rs. 1.35 crore, Rs. 5.54 lakh and Rs. 45 lakh, respectively. The quantity and their values have more or less remained the same since 2015.The minister held Rs. 9 crore and Rs. 8 crore as company deposits in Empro Oils and DCM Shriram, respectively, same as that declared in 2015. His public provident fund amount was Rs. 3 lakh more at Rs. 25.69 lakh in 2016. Immovable AssetsJaitley’s immovable assets, like his residential and commercial properties, had the same market valuation in both assessment years. He owned six residential properties (jointly with his wife) in Delhi, Gurgaon, Amritsar and Gandhinagar, apart from land in Haryana, and commercial properties across cities.
IndiGoIndia’s low-cost carrier, IndiGo is considering investing in Jet Airways if it fails to acquire a stake in Air India. With this move, the carrier aims to expand its international footprint, Mint reported.InterGlobe Aviation– the parent company of IndiGo– run by aviation entrepreneurs Rahul Bhatia and Rakesh Gangwal, was the first to show interest in Air India on the same day the government decided to sell a stake.IndiGo has a great chance to crack the Air India deal with new foreign direct investment (FDI) policy on aviation in sector in place. The new FDI policy says that rule allowing foreign airlines to invest up to 49 percent in an Indian airline does not apply to Air India, which rules out all the possibilities of a foreign airline buying into India’s national carrier, the business daily reported.A senior official, who was briefed on IndiGo’s strategy, told Mint that the airline will take the organic route if it can’t acquire a stake. But the process would be slower, he added.Currently, the foreign airlines fly about 65 percent of international passengers in and out of India. The rest is mostly carried by the state-owned Air India and Jet Airways.Given the circumstances, IndiGo would go all out to get Air India’s international business as the state-owned carrier has international flying rights and slots, the official said.Another alternative could be Jet Airways. IndiGo “sees an opportunity there” in a year, he said. Earlier in 2013, Jet sold 24 percent stake to Etihad.In case, neither of the options work out, IndiGo would like to start international operation on its own by buying bigger planes from Airbus or Boeing. But that will be a “very slow process” and it will be the last resort for the airline, he said.With a fleet of 139 planes, IndiGo is currently the largest domestic airline in India. To build managerial bandwidth IndiGo has roped in several experts from the US and other markets in departments such as finance, commercial, airports and flight operations.
A worker arranges food packets inside a retail store in Kolkata.ReutersThe Finance Ministry has decided to hike import duties on 19 non-essential items that include imported ACs, refrigerators, washing machines and others in order to curb widening current account deficit (CAD) and a weakening rupee.The hike in import duties varies from five per cent to 25 per cent and changes in rates are effective from September 27 (Thursday). The aviation fuel attracted five per cent hike. The increase, however, is not expected to increase airfare.As per the revised import duty rate, footwear attracted five per cent hike. Hike imposed on AC, refrigerator, washing machine, household items of plastics (tableware and kitchenware), office stationery and others may see public spending a little money from now. Union Finance Minister, Arun Jaitley.ReutersIt needs to be noted that Finance Minister Arun Jaitley while announcing measures to increase capital inflows and check rupee volatility earlier this month, had said that an extensive policy had been made to cut non-essential imports and boost exports.The move comes against the backdrop of the CAD touching 2.4 percent in the June quarter. The import duty hike is part of one of this policy measures.Following are the 19 items that are slightly expensive from Thursday.ItemItemPresent rate (%)Present rate (%)Revised rate (%)Revised rate (%)ItemAir conditionersPresent rate (%)10Revised rate (%)20ItemHousehold refrigeratorsPresent rate (%)10Revised rate (%)20ItemWashing machines less than 10 KgPresent rate (%)10Revised rate (%)20ItemCompressor for air conditioners and refrigeratorsPresent rate (%)7.5Revised rate (%)10ItemSpeakersPresent rate (%)10Revised rate (%)15ItemFootwearPresent rate (%)20Revised rate (%)25ItemRadial Car TyresPresent rate (%)10Revised rate (%)15ItemNon-industrial diamond (other than rough diamonds), i.e., cut and polished diamondPresent rate (%)5Revised rate (%)7.5ItemDiamonds-semi processed, half cut or brokenPresent rate (%)5Revised rate (%)7.5ItemLab-grown diamondsPresent rate (%)5Revised rate (%)7.5ItemCut and polished Colored gemstonePresent rate (%)5Revised rate (%)7.5ItemArticles of jewellery and parts thereof, of precious metal or of metal clad with precious metalPresent rate (%)15Revised rate (%)20ItemArticles of Goldsmith or silversmith wares and parts thereof of precious metal or of metal clad with precious metalPresent rate (%)15Revised rate (%)20ItemBath, shower bath, sink, wash basin, etc. of plasticsPresent rate (%)10Revised rate (%)15ItemArticles of plastics for conveyance and packing such as boxes, case, containers, bottles, insulated ware etc.Present rate (%)10Revised rate (%)15ItemTableware, kitchenware and other household items of plasticsPresent rate (%)10Revised rate (%)15Itemoffice stationery, fitting for furniture’s, decorative sheets, statuettes, beads, bangles etc.Present rate (%)10Revised rate (%)15ItemTrunks, Suitcase, Executive cases, Brief Cases, travel bags and other bags etc.Present rate (%)10Revised rate (%)15ItemAviation turbine fuelPresent rate (%)0Revised rate (%)5 Washing machines less than 10 Kg1020 Diamonds-semi processed, half cut or broken57.5 Tableware, kitchenware and other household items of plastics1015 Non-industrial diamond (other than rough diamonds), i.e., cut and polished diamond57.5 office stationery, fitting for furniture’s, decorative sheets, statuettes, beads, bangles etc.1015 Radial Car Tyres1015 Articles of Goldsmith or silversmith wares and parts thereof of precious metal or of metal clad with precious metal1520 Trunks, Suitcase, Executive cases, Brief Cases, travel bags and other bags etc.1015 Speakers1015 Cut and polished Colored gemstone57.5 ItemPresent rate (%)Revised rate (%) Bath, shower bath, sink, wash basin, etc. of plastics1015 Articles of jewellery and parts thereof, of precious metal or of metal clad with precious metal1520 Air conditioners1020 Lab-grown diamonds57.5 Household refrigerators1020 Footwear2025 Compressor for air conditioners and refrigerators7.510 Articles of plastics for conveyance and packing such as boxes, case, containers, bottles, insulated ware etc.1015 Aviation turbine fuel05
Students sit for a public examination. Prothom Alo File PhotoQuestion paper leaks have become a regular phenomenon in the country’s public examinations of late, while many question papers are printed full of errors, leaving the nation’s education system in jeopardy.Until now, these acts-students copying from others’ scripts, teachers telling examinees the answers, or question papers going outside the exam centres-were done covertly. However, the situation has worsened and leaked question papers are now sold on social media or at the dormitories in the open.The number of public exams has increased in the country, which means the number of examinees has increased as well. About 7.5 million students are appearing for four public exams – PEC (Primary Education Completion), JSC (Junior School Certificate), SSC (Secondary School Certificate) and HSC (Higher Secondary Certificate).Numerous faults in the question papers and wholesale adoption of unfair means are creating social instability. However, the education ministry, the primary and mass education ministry, and the education boards-all are failing to take effective measures to address the problem.There was a rumour that the question paper of PEC’s Science exam held on Wednesday was also leaked.Md Sohrab Hossain, secretary at the education ministry’s Secondary and Higher Education Division, told Prothom Alo on Wednesday, “Leaking of question papers cannot be prevented in the current process. We have formed committees to check the feasibility of having separate question papers for different exam centres. We shall take steps once we get their report.”Question papers full of errorsThe Bangladesh and Global Studies question paper in the ongoing PEC exam was full of errors.One of the questions there read, ‘What would happen if no the Mujibnagar govt. was formed’.In another question, the ‘liberation war’ was written as ‘freedom fight’.There were several other mistakes, and these mostly happened in Sylhet and Narayanganj areas.Seeking anonymity, two school teachers of English version told Prothom Alo that this was not the only time an English question paper was full of errors. Rather, this happens very often as the translators are not that skilled.Another question read, ‘What was the consequence of the British policy ‘divide and rule’ here?’ and the options were racial discrimination, social discrimination, cultural discrimination and economic discrimination. Students got confused by these options. In most cases incompetent people are being recruited as teachers and education officers, which is worsening the situation further, former professor of Dhaka University’s Institute of Education and Research (IER), Siddiqur Rahman, told Prothom Alo.Qualified people who are morally upright should be appointed to such posts, he observed.The National Academy of Primary Education (NAPE) at Mymensingh prepares the question papers for the PEC exams. As many as eight sets of question papers are printed and used at different locations. It’s the education officers who translate these question papers.NAPE managing director Md Shah Alam acknowledged the mistakes.“It is true that it was a big mistake. But, they cannot see the question papers,” he said, adding that they would look into the issue and take necessary steps.The Home Science question paper of the recently concluded JSC exam was full of errors as well.Last year there were 11 errors in the Mathematics question paper of Jessore Board, five in the Physics question paper of Dhaka Board, seven in Bangla question paper of Rajshahi Board, and 11 in the Bangla and English versions of the Mathematics question paper of the Chittagong Board.At several places exams were held with two-year-old questions. This also happened in 2012 at Kurigram and Habiganj disctricts, and Dhaka’s Keraniganj.Tapan Kumar Sarkar, controller of examinations of the Dhaka education board, said, “We take a number of steps, including blacklisting the people responsible for the errors.”Leaks in days prior to examInvestigation reveals that question papers are not leaked only on the morning of the exam days, but in some instances, as many as two or three days before as well. Along with BG (Bangladesh Government) Press and exam centres, persons at the distribution level are also involved in the leaking.Previously, question papers of one or two subjects used to be leaked occasionally but since 2012 the trend has changed. Question papers of almost all the subjects are being leaked these days.A detective branch (DB) official of Dhaka Metropolitan Police (west) told Prothom Alo they detained Gazirchot AM High School and College principal Md Mozaffar Ahmed and eight others on 27 March for their alleged involvement in question paper leaking.The detainees informed police that being secretary of a centre of the last SSC examination, Mozaffar Ahmed, along with one of his office assistants, would go to collect question papers from Savar model police station early on exam day. The then Savar upazilla secondary education officer was one of the question paper distributors there.Principal Mozaffar Ahmed and his office assistant would collect the next exam’s question papers along with the questions of the respective day’s exam and spread that around. Police also found that they used their facebook IDs to disseminate sample questions the night before the exams.Police investigation also revealed that sometimes the same teachers are appointed to prepare question papers for several years. They share the questions with students of their schools and coaching centres in the name of giving suggestions.The investigation also revealed that there is a chance of leaking during the typing of questions at the BG press.Two high-ups of the education ministry and secondary and higher secondary education board of Dhaka acknowledged they changed the English question paper of the SSC exam on exam day as it was leaked the previous night.Earlier in 2014, English and Mathematics question papers of HSC exams were leaked the night before the exams. But from 2015 onwards, some teachers have been breaking the seals of packed question papers just 1-2 hours before the exams and sending out images of the questions. The same happened in the recently concluded JSC MCQ (multiple choice question) exam.“[People used to] leak question papers before too, but that was limited. It has increased recently. A good student gets frustrated when he sees that a bad one is doing well getting leaked questions. [As a result] they lose confidence as they grow up. Quality of education is being severely hampered,” said BUET (Bangladesh University of Engineering and Technology) professor M Kaykobad.Education minister Nurul Islam Nahid, however, said on several occasions that some miscreants known as teachers are leaking questions on the exam days. They are under surveillance and being seized.Identical question might act as boomerangThe education ministry plans to print question papers at the centres on the day of a public exam, to curb the trend.Several officials of the education ministry, though, informed that the plan will not be implemented in the next SSC exam. BG press will print the question papers again.As eight boards will use identical question papers in the next SSC exam, officials of the education ministry suspect the situation will worsen. Questions leaked at one place will spread quickly across the country and create havoc.*This piece, originally published in the Prothom Alo print edition, has been rewritten in English by Nusrat Nowrin
Bangladesh Awami general secretary Obaidul Quader. File PhotoAwami League general secretary Obaidul Quader on Saturday said BNP has nothing other than complaining to foreigners after its failure in both the election and its movement, reports UNB.He also described the remarks of BNP secretary general Mirza Fakhrul Islam Alamgir over the national election as ‘delirium of a failed politician’.Quader, also the road transport and bridges minister, came up with the remarks while talking to reporters before a joint meeting of Awami League presidium members and the party’s different associate bodies at its Bangabandhu Avenue office.”They (BNP) couldn’t wage a movement over the last 10 years. We thank them as they joined the national election. But they utterly failed in the election, too,” he said.Quader further said, “What can be their (BNP’s) resort now as they have failed in its movement and the election? Now they’re complaining to foreigners and it’s their old habit.”He said the Awami League was more united during the 11th parliamentary election than in the past. “We achieved a massive victory as we could show a stronger unity through excellent coordination under the leadership of Sheikh Hasina.”The Awami League general secretary said their president Sheikh Hasina’s strong stance against evil and communal forces also helped the party get an unforgettable victory in the election.The minister said their party will celebrate the victory through a rally at Suhrawardy Udyan on 19 January.At the beginning of the meeting, one minute silence was observed paying homage to party former secretary general Syed Ashraful Islam.Four days after being elected an MP of the 11th parliament, Awami League presidium member and public administration minister Syed Ashraful Islam died of lung cancer at a hospital in Thailand on Thursday night at the age of 67.
Share Twitter User @umamistreetfoodThanksgiving is perhaps the quintessential American holiday. The fourth Thursday in November provides a moment to reflect on the good fortune of the past year and a chance to share a meal with friends and family. Iconic images of Thanksgiving place America’s native bird, the turkey, at the center of the feast, as are corn, pumpkins and other indigenous species. Unlike other holidays including Valentines Day, Halloween and even Christmas, though, the flavors of Thanksgiving are savory rather than sweet. And just as there is a history to the Thanksgiving menu, so too, there is a history to the holiday’s primary taste: umami. Most Americans are taught, although this is changing, that there are four basic tastes: sweet, sour, salty and bitter. However, more than a century ago, the Japanese chemist Kikunea Ikeda posited a fifth primary taste, which he called umami. In an effort to describe this new taste in 1912, he suggested: “An attentive taster will find … something common in the complicated taste of asparagus, tomato, cheese, and meat, which is quite peculiar and cannot be classified under any of the above mentioned qualities sweet, sour, bitter, or briny. It is usually so faint and overshadowed by other stronger tastes, that it is often difficult to recognize it unless the attention is specially directed towards it. “The existence of umami as a basic taste like sweet, sour, salty or bitter seems “new” to the American palate. But in my research on US food systems in the 20th century, I’ve found that the recognition of umami followed the spread of Asian cuisine in the US decades ago. A taste is bornIn order to better explain this subtle taste, Ikeda attempted to describe the difference between umami as it is found in food and its pure form. By way of analogy, he explained: “Had we nothing sweeter than carrots or milk, our idea of the quality of “sweet” would be just as indistinct as it is in the case of this peculiar quality. Just as honey and sugar gave us so clear a notion of what sweet is, the salts of (the amino acid) glutamic acid are destined to give us an equally definite idea of this peculiar taste quality. “Based on over two years of research, he was convinced that another – “new” – basic taste existed. He found umami in “fish, meat and so forth” or in foods with high-protein content. Ikeda’s “discovery” of umami was based as much on his mastery of physical chemistry as it was on his own taste experiences and the flavors endemic to Japanese foods. Japanese cuisine, more than European and Eurocentric cuisines, is centered on umami as a foundational element and is a key taste in the Japanese palate. The two foods Ikeda focused on to extract glutamic acid were konbu and bonito, the key elements in dashi – a savory broth ubiquitous throughout Japanese cooking. As it happens, both konbu (a dried brown kelp) and katsuobushi (bonito or skipjack tuna which is fermented, dried, smoked and flaked) contain large amounts of glutamic acid. In fact, miso soup, a twice-daily habit in most Japanese households even today, is a combination of two strong umami flavors, dashi and miso (a fermented soy paste). Ikeda also singled out soy sauce as a food that amplifies umami. In particular, soy sauce, with its high salt and glutamic acid content, was an excellent example of how salt intensified the taste of umami. As research in umami took hold in the second half of the 20th century, scientists found that umami was far more complex than any of the other basic tastes. One of the first major breakthroughs was the discovery that compounds other than glutamic acid produce umami. For example, both MSG – a combination of salt and glutamic acid – and other acids each produce distinct umami flavors. But when they are combined, the perception of umami is more than the sum of its parts. No other basic taste has this capability to ratchet up taste perception. Getting to know umami in the USIkeda’s and the Japanese palate was trained to experience umami, unlike palates in either Europe or the United States. By the end of the Vietnam War, though, shifting immigration patterns to the United States included more East Asians from Japan, Thailand, Vietnam, Taiwan, China and South Korea. These immigrants brought a variety of new cultural influences to the US, particularly on the West Coast. By the mid-1980s, when Japan Inc dominated headlines and was thought to threaten American prosperity, Chinese restaurants were more common than Italian ones, and sushi, whether loved or reviled, defined Japanese food for most Americans. Immigration and assimilation of East Asian flavors into American cuisine as well as a plethora of industrial foods that incorporated glutamates made umami a far more common taste and altered the American taste landscape and the American palate in the late 20th century. Eating soy sauce, tofu, fish sauce and other foods high in glutamates not only integrated East Asian flavors into the American palate but also wove those communities into America’s social fabric through the sense of taste. It took until the early 2000s for the scientific community to recognize umami as the fifth taste. So as you are eating your Thanksgiving turkey with gravy and relishing all the side dishes, such as mushrooms, brussel sprouts or stuffing, that make the meal delicious, remember the savory taste of umami only became obvious once Americans assimilated the flavors of distant lands into their everyday lives. That’s something for which we can all be thankful. This article was originally published on The Conversation. Read the original article here: http://theconversation.com/the-asian-roots-of-umami-the-fifth-taste-central-to-thanksgiving-fare-50699.
Share Alexei Nikolsky/APRussian President Vladimir Putin gives his annual state of the nation address in Moscow on Thursday.An aide to Russian President Vladimir Putin said Monday that U.S. President Donald Trump invited the Russian leader to the White House when they spoke by telephone last month, but the two countries haven’t started any preparations for such a visit.Trump and Putin had a telephone conversation on March 20 in which Trump congratulated Putin on winning the Russian presidential election two days earlier. The White House and the Kremlin said at the time the two presidents discussed meeting in person.Trump specifically invited Putin to the White House during the call, Putin aide Yuri Ushakov told Russian news agencies Monday.However, their governments didn’t have time to start arranging a meeting before the United States joined Britain and more than two dozen allies in sanctioning Russia over the nerve-agent poisoning of a Russian ex-spy in England, Ushakov said.White House Press Secretary Sarah Huckabee Sanders confirmed that Trump invited Putin to Washington during the call, but said the White House was among “a number of potential venues” the two leaders discussed for a bilateral meeting.“As the President himself confirmed on March 20, hours after his last call with President Putin, the two had discussed a bilateral meeting in the ‘not-too-distant future’ at a number of potential venues, including the White House,” Sanders said, adding that the administration had no further comment on the matter.Some Republican lawmakers criticized Trump for making the congratulatory call to Putin. Trump defended his decision on Twitter, saying President Barack Obama did the same in 2012.During the call, Trump didn’t raise Russia’s meddling in U.S. elections or its suspected involvement in the poisoning of the former spy and his daughter in Britain.
The research team – Adelene Y. L. Sim in the Department of Applied Physics, and Prof. Michael Levitt and Dr. Peter Minary in the Department of Structural Biology – faced a range of challenges in devising their unique algorithm. Speaking with PhysOrg, Minary and Sim describe those challenges. “Reducing dimensionality may eliminate physically relevant paths connecting conformational basins and therefore introducing artificial energy barriers that do not present obstacles in Cartesian space,” Minary tells PhysOrg. “In the present case, the major challenge was to develop an algorithm that supports degrees of freedom representing arbitrary collective rearrangements at all-atom resolution.”Unfortunately, Minary notes, using these degrees of freedom, or DOFs, could break chain connectivity – and the corresponding conformational space is likely to be associated with extremely rough energy surface topology. “To overcome these limitations,” he adds, “less collective rearrangements need to be utilized only at a necessary extent so that rearrangements along the more collective DOFs are optimally facilitated without significantly increasing the volume of the sampled conformational space.” In short, their major challenge was implementing a universal algorithm capable of exploring conformational space while allowing numerous sets of arbitrary and/or user-defined so-called natural DOFs.The team addressed these issues, Minary says, by building on the preexisting high-level computational environment of the MOSAICS software package that enabled the use of arbitrary even chain breaking DOFs. “To further improve on this concept,” he adds, “a very flexible new interface had to be invented that welcomes users to define their own system specific DOFs. In addition, the interface also had to support the weighted superposition of arbitrary DOFs. Finally a universal algorithm that realizes the interaction of various sets of DOFs needed to be implemented.” By so doing, conformational paths along the most collective molecular rearrangements are augmented by the incorporation of progressively more detailed molecular flexibility without significantly altering the dimensionality problem, which is better quantified by the conformational volume to be sampled rather than the actual number of DOFs. Effects of adding hierarchical degrees of freedom on sampling a large symmetric RNA structure. (A) Hierarchical moves used. A system of this complexity has many possible collective motions. Here seven sets of independent degrees of freedom (L1 to L7) are defined. (B) Convergence is accelerated by higher order rigid body moves. When nested hierarchical moves L1 to L7 were used, rapid convergence to the limiting is reached within 2 × 104 iterations (vertical dashed line labeled *). Image Copyright © PNAS, doi: 10.1073/pnas.1119918109 Other innovations are also in the works. “In the current paper we showed that our algorithm satisfies some necessary conditions of phase space, or detailed balance, preserving sampling not satisfied by any of the available algorithms used to model RNA systems,” Minary notes. “Further efforts are invested to fully satisfy microscopic reversibility.” Moreover, computational efficiency may be improved by using information on the collective nature of DOFs when updating atomic interactions, or by defining energy functional forms in terms of low dimensional analytical coordinates. Minary points out that sampling efficiency could also be improved if the current approach is combined with some advanced sampling algorithms based on multi-canonical sampling available in MOSAICS.In addition, he continues, the movement of explicit water could be incorporated into the hierarchical moves so that effects of solvation can be more accurately evaluated – and testing the method with various implicit solvent representations may also be informative. “Finally,” he says, “we’re planning to introduce a more user friendly – possibly graphical – interface that would bridge the gap between algorithm developers and computational biologists, physicists and chemists who have great insight and intuitions about the natural DOFs of various molecular assemblies and complexes.” Altogether, all the above efforts, which would increase mathematical rigor, computational speed, solvent details and accessibility to users, could further extend the boundaries of applications beyond the current systems being considered.In the meantime, while developing all the necessary algorithms discussed above, the team plans to continue extending the range of target applications. “Besides modeling the structure of chromatin,” Minary illustrates, “we’d like to revisit questions in DNA nanotechnology.” Furthermore, the use of a refinement method other than Cryo-EM (Cryo-Electron Microscopy, a form of transmission electron microscopy where samples are studied at cryogenic temperatures, and which the team is already pursuing) is also planned. “We intend to extend our work to extensively explore RNA junction flexibility,” adds Sim, “and are also currently looking into using our technique in RNA structure prediction of large RNA systems.” In terms of applications, Sim continues, “in medicine it’s vital to understand the flexibility, stability, shape and possible distortions of nanostructures to better evaluate the nanostructure quality. These properties could play crucial roles in dictating cellular internalization and/or toxicity of nanostructures.”Sim points out that with their efficient modeling tool, although still dependent on the quality of the force field used, the team is now more capable of studying these properties in silico. “Additionally,” Sim notes, “we’re looking into optimization in sequence- and structure-space simultaneously by having sequence as an additional degree of freedom.” A possible application is the sequence design of silencing RNA, or siRNA.Looking further afield, Minary tells PhysOrg, there are other technologies and applications that might benefit from their findings. “Since proper sampling and exploration of the conformational space is a basic tool used in various technologies and applications, the method could be used in design, homology modeling and various new applications such as modeling collective rearrangements in trans-membrane proteins, designing new nucleic acid nanostructures, modeling large protein-nucleic acid assemblies, such a the ribosome, and the in silico study of chromatin remodeling. In addition,” he adds, “we’d like to aid the refinement and interpretation of experimental techniques.” Specifically, building on former efforts to refine Cryo-EM data, they’d like to develop tools to analyze NMR, FRET, SAXS, X-Ray, and footprinting experiments in order to generate conformational ensembles that satisfy experimental constraints. Finally, Minary points out that the algorithm they developed is very general in nature and could be also utilized in other disciplines that involve state spaces with a large number of variables that are changing in a correlated manner. “In particular,” he concludes, “the basic idea could be used but not limited to sampling the space of possible networks, as in systems biology applications, or stock market variables.” More information: Modeling and design by hierarchical natural moves, PNAS February 21, 2012 vol. 109 no. 8 2890-2895, doi: 10.1073/pnas.1119918109Related:The effects of polymeric nanostructure shape on drug delivery, Advanced Drug Delivery Reviews, Volume 63, Issues 14–15, November 2011, Pages 1228–1246, doi: 10.1016/j.addr.2011.06.016 Square-Shaped RNA Particles from Different RNA Folds, Nano Letters, February 24, 2009 (Web), 9 (3), 1270–1277, doi: 10.1021/nl900261h Citation: Modeling the miniscule: High-resolution design of nanoscale biomolecules (2012, March 12) retrieved 18 August 2019 from https://phys.org/news/2012-03-miniscule-high-resolution-nanoscale-biomolecules.html Explore further Swimming upstream: Flux flow reverses for lattice bosons in a magnetic field This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. (PhysOrg.com) — A key element of both biotechnology and nanotechnology is – perhaps unsurprisingly – computational modeling. Frequently, in silico nanostructure design and simulation precedes actual experimentation. Moreover, the ability to use modeling to predict biomolecular structure lays the foundation for the subsequent design of biomolecules. Historically, the problem has been that most modeling software presents a tradeoff between being general purpose (in being able to model systems at high/atomic resolution) but limited in scope (i.e., only explores a small fraction conformational space around the initial structure). Recently, however, Stanford University scientists have developed an algorithm – implemented in a modeling program known as MOSAICS (Methodologies for Optimization and SAmpling In Computational Studies) – that achieves nanoscale modeling at the resolution required without being limited by the scope/size dilemma. In addition, the researchers successfully modeled – and benchmarked the new computation modeling technique with – RNA-based nanostructures. Copyright 2012 PhysOrg.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com.
Citation: Amphibious fish found to use evaporative cooling to overcome hot water (2015, October 21) retrieved 18 August 2019 from https://phys.org/news/2015-10-amphibious-fish-evaporative-cooling-hot.html Mangrove rivulus. Credit: Wikipedia There are many varieties of amphibious fish—those fish that jump or crawl out of the water to hang out on land for awhile, but until now, no one has seen an example of one that jumps out of the water to use evaporative cooling to chill its body after swimming in water that was too hot. Prior research had shown that mangrove rivulus jump (or more accurately flip themselves out of the water by bending then releasing quickly) but it was not clear why they did so—other amphibious fish have been known to get out of the water if CO2 build up, or if there were pollutants, or even to snag a meal, but that did not seem to apply to the mangrove rivulus.To find out more about the fish (which look sort of like tadpoles) the researchers raised some specimens for a year in tanks in their lab, at a temperature of 25 or 30°C and also collected wild adults and put them in tanks in their lab too, and acclimated them for a time at the same temperature as those they had raised. Then, they watched and filmed (with a thermal imaging camera) what happened as the temperature of the water was raised. The fish, as expected hurled themselves out of the tank onto “shore”—when the temperature reached approximately 36°C. The researchers also enclosed the fish tanks so that they could create different levels of humidity and found that the fish cooled better in lower humidity environments. They also found that despite high humidity, the fish could all cool themselves down to ambient temperature within minutes. In studying the fish, the researchers found that not only was it able to use evaporative cooling, but its behavior also demonstrated plasticity, because it was dependent on recent acclimation history rather than conditioning when they were young. This suggests the fish is remarkably well suited to handling warmer waters as the planet heats up. More information: Out of the frying pan into the air—emersion behaviour and evaporative heat loss in an amphibious mangrove fish (Kryptolebias marmoratus), Biology Letters, Published 21 October 2015.DOI: 10.1098/rsbl.2015.0689 AbstractAmphibious fishes often emerse (leave water) when faced with unfavourable water conditions. How amphibious fishes cope with the risks of rising water temperatures may depend, in part, on the plasticity of behavioural mechanisms such as emersion thresholds. We hypothesized that the emersion threshold is reversibly plastic and thus dependent on recent acclimation history rather than on conditions during early development. Kryptolebias marmoratus were reared for 1 year at 25 or 30°C and acclimated as adults (one week) to either 25 or 30°C before exposure to an acute increase in water temperature. The emersion threshold temperature and acute thermal tolerance were significantly increased in adult fish acclimated to 30°C, but rearing temperature had no significant effect. Using a thermal imaging camera, we also showed that emersed fish in a low humidity aerial environment (30°C) lost significantly more heat (3.3°C min−1) than those in a high humidity environment (1.6°C min−1). In the field, mean relative humidity was 84%. These results provide evidence of behavioural avoidance of high temperatures and the first quantification of evaporative cooling in an amphibious fish. Furthermore, the avoidance response was reversibly plastic, flexibility that may be important for tropical amphibious fishes under increasing pressures from climatic change.Press release This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Journal information: Biology Letters (Phys.org)—A team of researchers affiliated with the University of Guelph and Brock University, both in Canada, has found the first example of an amphibious fish using evaporative cooling to chill its overheated body. In their paper published in the journal Biology Letters, the researchers describe their study that included raising Kryptolebias marmoratus, aka mangrove rivulus, to adulthood and then testing them by heating the water in which they lived. © 2015 Phys.org Explore further Flipping fish adapt to land living (w/ Video)
Last updated on June 27th, 2019 at 12:57 pmThe state Department of Transportation has stripped Milwaukee auto wholesaler Cuzco Auto Mart of its wholesale license after an investigation determined the company altered mileage on 136 vehicles.An order from the Department of Administration’s Division of Hearings and Appeals, said the representatives of the business, located at 5032 W. Forest Home Ave., did not show up for a hearing in December.According to the order, DOT investigators determined Cuzco Auto Mart purchased 136 vehicles at auction and then resold the vehicles after tampering with odometers and changing title information to reflect lower mileage. In total, Cuzco shaved 9,138,966 miles off of the 136 vehicles, an average of more than 67,000 per vehicle.The vehicles were then sold directly to Illinois retail customers. Cuzco does not have an Illinois used vehicle license, according to the order.The order says the case was “filled with revocable violations” and “the sheer volume of these violations prompted DOT to summarily suspend Cuzco’s license immediately.” Get our email updatesBizTimes DailyManufacturing WeeklyNonprofit WeeklyReal Estate WeeklySaturday Top 10Wisconsin Morning Headlines Subscribe