Boss Arsene Wenger says Mesut Ozil will return to the Arsenal squad when they host Chelsea on Sunday, but Alexis Sanchez may not be risked.Ozil has fully recovered from the foot injury that kept him out of last weekend’s 0-0 draw at Stoke and will definitely be involved.Sanchez is also close to full fitness, having been sidelined since November, but Wenger admitted it would be a gamble to play him against the Blues.He said: “The doubt is that he has been out for a long time and [there is] the risk of a setback if you try to go too early.“To be clear on all the tests is one thing, training is another thing, and after that the intensity of a big game which you can never repeat in a training session.“I am cautious with him because we cannot afford a setback with him. A setback would mean a very long period out so we don’t want to take this gamble.”Wenger also confirmed Francis Coquelin returned to full training on Thursday, with Danny Welbeck doing likewise next week. Tomas Rosicky is also ruled out of the Chelsea match.See also:Costa and Hazard passed fit for Arsenal clashArsenal v Chelsea: match preview, team news, facts and figuresFollow West London Sport on TwitterFind us on Facebook
The Eureka Municipal Golf Course may soon be operated and maintained by the Community Access Project for Eureka, also known as CAPE, a nonprofit that works with the city to provide quality of life programs and opportunities to the community.Miles Slattery, the city’s community services director, said CourseCo, which has leased and operated the golf course for twenty years, has opted out of their lease after sustaining financial losses for the last several years as the golf industry slumped.“Th …
Khanyi Magubane The forceful thrust of South African cellphone network operator MTN into the global telecommunications arena has not only taken its competitors by surprise, but it has also proved that calculated risks do pay off. Following a slow start since its inception in 1994, MTN took off rapidly in 2002 with remarkable expansion into Africa and the Middle East. Bolstered by a new vision-driven Chief Executive Officer, Phutuma Nhleko, the network operator went into over-drive to not only reposition itself, but to set new trends.Under Nhleko’s direction, MTN has expanded aggressively into markets that are sometimes deemed volatile – but the risk has paid off. Now MTN operates in 21 countries in these two regions: Botswana, Cameroon, Cote d’Ivoire, Nigeria, Republic of Congo, Rwanda, South Africa, Swaziland, Uganda, Zambia, Afghanistan, Benin, Cyprus, Ghana, Guinea Bissau, Guinea Republic, Liberia, Sudan, Syria, Yemen and Iran. The MTN group has operations in 21 countries in Africa and the Middle East.Over the past six years the company’s share price has risen more than ten times in value since Nhleko was appointed. MTN is now worth an estimated R250-billion ($US32-billion), making it the sixth-biggest company listed on the Johannesburg Stock Exchange and putting it among the 10 largest mobile phone operators in the world.Setting up shop in developing countries has paid off in monetary terms for the company. For the year ending 31 December 2007, the group reported operating earnings of R31,8-billion ($4.08-billion) on revenue of R73, 1-billion ($9.34-billion), an operating margin of close to 45%.Fending off the bigger players Besides obtaining operating licenses in the different global regions, the group is also keen on making acquisitions in countries that it hopes to expand into. Nhleko’s acquisition plans include buying assets in Southeast Asia and Central America. Analysts are predicting that the company will also target Pakistan and India – both countries have low telephone penetration.The network’s main objective at the moment is to continue cementing its position as a global telecommunications player, in a bid to prevent the company from being swallowed up by bigger players. Speaking to Financial Mail, Nhleko said, “We do not have a ‘for sale’ sign up. But, being a publicly listed company, we can’t say if someone approached the company, the shareholders would necessarily be in agreement with management to sell or not to sell. Our job is to manage the company and grow the values until the shareholders tell us differently.” MTN’s success has attracted the attention of other international telecommunication companies in the industry. China Mobile, the world’s largest operator by subscriber number (it has an estimated 400 million users) is believed to be in serious talks with MTN. The talks allegedly started 18 months ago although both parties have been silent on the topic.The UK’s Vodafone, which currently holds 50% of Vodacom (MTN’s biggest competitor in South Africa), is believed to be cajoling the network into allowing it to buy a stake in its operations outside of South Africa. MTN has, however, denied this. As at 31 March 2006, MTN recorded more than 28 million subscribers across its operations, including those of the newly acquired Investcom LLC. In the last quarter of 2006, the network launched commercial operations in Iran, following the successful purchase of a 49% shareholding in Irancell. Growth has been so phenomenal that it is estimated that by the end of this year MTN will have more subscribers in Iran than South Africa.Since operations started in that country 18 months ago, the network operator now has nine million users. South Africa currently has 14,8-million users. With rapid expansion though comes the challenge to continually provide the infrastructure for an efficient service. To this end, MTN intends spending more than R30-billion this year alone on expanding its infrastructure and improving the quality of its coverage.The group has of late come under fire from regulatory bodies, especially in Nigeria, to improve the quality of its services or pay the fines. Nigeria is one of the network’s biggest markets. MTN Nigeria, one of four cell phone networks in the West African country, has been operating since 2001.During the period under review, MTN Nigeria aggressively focused on subscriber growth, supported by rapid network roll out amid keen competition in the market. As a result, the company significantly increased its subscriber base from 5,6 million to 8,4 million currently.In February 2008, in a bid to empower Nigerians, MTN South Africa reduced its stake in MTN Nigeria to 76,08%. Nigerian individuals and key institutions acquired a 9,45% interest in MTN Nigeria from MTN. The company said that it had sold 5,96% in MTN Nigeria as part of a US $594,5-million (R4.632-billion) private placement.The man taking MTN forwardPhutuma Nhleko first became involved with MTN by way of Worldwide Africa’s investment in Johnnic (now Avusa). Nhleko, along with top businessman Wiseman Nkuhlu, founded Worldwide in 1994 as one of the first black empowerment investment companies in South Africa. The company, of which Nhleko still remains a major shareholder, invests in various energy and technology companies across sub-Saharan Africa. Nhleko is described by industry insiders as driven and determined. Colleagues say he contemplates everything deeply and methodically but is not afraid to take risks once he’s weighed all his options and is certain of the move he is about to make. His deal-making skills were honed at Standard Bank, where he worked from 1990 until he started his own company in 1994 but his background is in engineering. He studied engineering at the University of Ohio in the US and also has an MBA from the University of Atlanta. Despite having achieved phenomenal success for MTN, Nhleko is reluctant to renew his contract when it expires in 2010, saying that by then the company will need someone younger and fresher with new ideas to take the company forward.Nhleko is not a one-man island at the company and works closely with a core group of seven:Rob Nisbet – Finance director. Nisbet is highly rated by analysts for the clear way he presents MTN’s financials.Sifiso Dabengwa – Chief Operating Officer. Since joining MTN in 1999, the Zimbabwe born Dabengwa has held a number of high profile posts within the company, including CEO of Nigerian operations.Karel Pieneer – Chief technology and information leader. He has been with the company since 1994 and is responsible for its technology choices.Santie Botha – Executive: Marketing. She joined the company in 2003, she oversees the groups’ multibillion rand marketing budget.Christian De Faria – Vice President: West and Central Africa. He joined the network operator in 2006, has a history of increasing turnover at XL, the largest mobile operator in Indonesia.Tim Lowry – MTN SA managing director and Vice President – South And East Africa. He comes with vast experience in the telecom industry. He has worked for a large number of European operators across the world.Jamal Ramadan – Vice President Middle East and Africa. He joined the company from Investcom and has experience heading up the IT departments of international telecommunication companies.Useful linksThe Empowerment Charter for the ICT SectorMTN South AfricaMTN globalDepartment of CommunicationsDo you have any queries or comments about this article? Email Khanyi Magubane at email@example.com
Keown: Daniel James will be regretting Man Utd moveby Paul Vegas18 days agoSend to a friendShare the loveArsenal title winner Martin Keown says Daniel James will be regretting his move to Manchester United.Keown reckons the Wales international is United’s youngest but best player. Heaping praise on James, Keown said on Match of the Day: “Daniel James must be thinking ‘who have I signed for here?’ “He’s their youngest player, but he’s their best player.”Manchester United were beaten 1-0 by Newcastle on Sunday. About the authorPaul VegasShare the loveHave your say
Saturday is #AveryStrong day for the Nebraska men’s basketball program. Avery Harriman, the 7-year-old son of Huskers’ assistant coach Chris Harriman, has battled leukemia since he was 2. He’s been an inspiration to Tim Miles’ team this season and the Huskers’ players are constantly interacting with their No. 1 fan. Saturday’s event will be part of the National Association of Basketball Coaches Suits and Sneakers Awareness Week. Chris Harriman says #Huskers players are constantly asking about Avery. “Its fun to see them be happy when hes doing well” #AveryStrong— Jake Bockoven (@jakebockoven) January 23, 2015Nebraska (11-7, 3-3 Big Ten) is set to host Michigan State (13-6, 4-2 Big Ten) in Lincoln Saturday. During the game, the Huskers’ students will be wearing #AveryStrong T-shirts. First 1,500 students. #GBR “@HuskerSports: Getting the shirts in place for #AveryStrong tomorrow. #Huskers” pic.twitter.com/SpUsRoHGml— Nebraska Huskers (@Huskers) January 23, 2015Nebraska and Michigan State are set to tip off at 4 p.m. E.T. The game will be televised on ESPN.
Mississippi State Hype VideoMississippi State suffered a tough loss to Georgia Tech in last year’s Orange Bowl, but all in all, the Bulldogs had a great season. MSU opened the 2014 campaign with nine straight victories, including wins over LSU, Auburn and Arkansas, before falling in a close contest to Alabama. The Bulldogs, in early November, were the No. 1 ranked team in the country. And they posted double-digit victories for just the second time in their program’s history.The 2015 Bulldogs aren’t being picked by many to be quite as successful, but with star quarterback Dak Prescott returning, they may surprise a few people. Thursday, the school released an awesome hype video titled “Relentless” to tease the 2015 campaign. Enjoy, MSU fans:
Spanish telco Telefónica has unveiled its Spanish football programming line-up but has yet to strike a deal with Catalan broadcaster Mediapro to carry its BeIN Sports channel, giving it access to European Champions League and Europa League matches as well as coverage of European and international leagues.The Liga Adelante offering on Telefónica’s Movistar+ service will include coverage of La Liga matches in HD, with 11 fixtures daily to be aired on the Canal+ Liga.Telefónica is also introducing eight-camera coverage of matches, with two mini-cameras providing coverage of the changing rooms of the teams for the final three minutes before they go out onto the field.The telco will also provide multiscreen coverage via Yomvi and the Movistar+ Fútbol App.Telefónica has yet to strike a deal with Mediapro to include BeIN Sports as part of its offering, despite the latter being available via the services of rival telcos Vodafone and Orange and Asturias region cable operator Telecable.According to sports news website Palco23, citing unnamed sources familiar with the negotiations, talks are stalled over the question of Mediapro’s demand for minimum guaranteed payments.
Source:https://www.tum.de/nc/en/about-tum/news/press-releases/detail/article/35173/ Reviewed by James Ives, M.Psych. (Editor)Jan 16 2019If a pregnant woman gains excessive weight, it can pose a problem for both the mother and child. As a solution, regular counseling appointments have been proposed. Based on results with 2286 women, a team of the Technical University of Munich (TUM) in cooperation with the Competence Center for Nutrition (KErn) has now shown that although counseling appointments as part of routine prenatal care can encourage a healthier lifestyle, it does not reduce weight gain.If a woman gains excessive weight during pregnancy, it could lead to gestational diabetes, an increased risk of cesarean section or excessive birth weight of the newborn. The goal of the Bavarian Healthy Living in Pregnancy Study (GeliS) was to make pregnant women aware of the problem and to improve their dietary behavior and physical activity. More than 70 medical and midwife practices in Bavaria participated in the study.Women in the study group received three counseling sessions (30?45 minutes each) from week 12 of pregnancy, followed by another consultation several weeks after childbirth as part of their preventive check-ups. They also received additional information material as well as forms that allowed them to independently record and monitor their weight gain and physical activity. The control group only received the information material.Slight reduction in newborn weightStudy Director Professor Hans Hauner, Professor of Nutritional Medicine at the TUM, explains the initial findings: “Unfortunately, the counseling concept proved unsuccessful and had no measurable effect on maternal weight gain.” Despite the counseling, over 45 percent of the participants gained more weight than recommended by the international standard of the Institute of Medicine (IOM) ? over 14 kilograms on average. Nor did the counseling lead to a reduction in complications such as gestational diabetes, hypertension or premature labor.Related StoriesPre-pregnancy maternal obesity may affect growth of breastfeeding infantsOpioids are major cause of pregnancy-related deaths in UtahNew research examines whether effects of alcohol/pregnancy policies vary by raceNevertheless, his research team did find some positive effects: An initial look at the extended data shows that many pregnant women did in fact pay close attention to their diet and exercised regularly. In addition, more than 85 percent of women continued the program to the end and readily took the advice they received to heart. “Evidently, that was not enough to reduce their weight gain. What we saw, however, was a reduction in the size and weight of the babies of the women who participated in the program. That, too, is a small but important achievement,” Hauner says. The study team also recommends that counseling sessions be started before the 12th week of pregnancy.Main criterion: suitability for routine useIn addition, a special feature of the study was the fact that the counseling sessions were integrated into routine prenatal check-ups. It is the largest study in the world to use this approach. “It was important to us that the concept be suitable for routine use. The pregnant women did not have to appear for any additional appointments, and the effort on the part of the doctors and midwives was well defined. Only such solutions are practicable. “Numerous studies have looked after and monitored pregnant women with the help of separate regular appointments,” Hauner says. “Even if that has a positive effect, it’s not a practical solution for all pregnant women ? and that should be the goal,” Hauner says.
Source:https://www.mdanderson.org/newsroom/castration-resistant-prostate-cancer-responds-to-immunotherapy-combination.h00-159300678.html Reviewed by James Ives, M.Psych. (Editor)Feb 15 2019Two checkpoint inhibitors provide early encouraging results for immunologically cold diseaseSome patients with metastatic prostate cancer respond to a combination of immune checkpoint inhibitors after hormonal therapy and chemotherapy have failed, according to early results from a clinical trial led by investigators at The University of Texas MD Anderson Cancer Center presented today at the American Society of Clinical Oncology Genitourinary Cancers Symposium in San Francisco.Principal investigator Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology at MD Anderson, said the results of combining the CTLA-4 blocking drug ipilimumab with the PD-1 inhibitor nivolumab provide an encouraging step for a cancer that’s been highly resistant to immune checkpoint therapies.Research by Sharma and 2018 Nobel Laureate Jim Allison, Ph.D., chair of Immunology, leaders of MD Anderson’s immunotherapy platform, provided a rationale for combining the two drugs. The platform is part of MD Anderson’s Moon Shots Program™, a collaborative effort to accelerate the development of scientific discoveries into clinical advances that save patients’ lives.Among castration-resistant patients who had progressed after second-generation hormonal therapy (cohort 1), 25 percent (8 of 32) had their tumors shrink from the immunotherapy combination at a median follow-up of 11.9 months. Among those who progressed after chemotherapy and hormonal therapy (cohort 2) 10 percent (3 of 30) had a response at median follow-up of 13.5 months.”This was the first combination trial of two immune checkpoint therapies in prostate cancer,” Sharma said. “These results support the idea that immune checkpoint blockade can play an important role in the treatment of these patients and provide the foundation to test this strategy in a larger clinical trial.”There were four complete responders, two in each cohort, among the 62 patients who could be evaluated for tumor growth.Side effects from the combination were consistent with those experienced in previous combination trials for other cancers, with 42 percent of patients in cohort 1 and 53 percent in cohort 2 experiencing grade 3 to 5 adverse events. Among cohort 1, 33 percent had to discontinue participation due to adverse events, with 35.6 percent having to withdraw from cohort 2. The most common adverse events were diarrhea, fatigue, skin rash, nausea and hypothyroidism. Four patients died from treatment-related adverse events, two in each cohort.Related StoriesResearchers identify potential drug target for multiple cancer typesLiving with advanced breast cancerStudy reveals link between inflammatory diet and colorectal cancer riskDisease progression was the most common reason to leave the trial, with 51.1 percent of cohort 1 and 44.4 percent of cohort 2 discontinuing for that reason.The researchers also analyzed a number of biomarkers and found that higher tumor mutational burden was associated with response.Combination heats up cold tumorIn previous clinical trials, neither drug succeeded as single therapy against prostate cancer, a so-called “cold” malignancy because it does not attract the attention of the immune system. Few T cells, the adaptive immune system’s targeted warriors, infiltrate prostate tumors.In a phase I trial, no patients responded to nivolumab alone because the PD-1 inhibitor requires an immune response to be under way in order to attack tumors.The multi-center combination clinical trial by Bristol-Myers Squibb, maker of both drugs, was organized after research published in Nature Medicine by Sharma and Allison, provided scientific underpinning for the combination in prostate cancer.Analyzing tumor samples before and after treatment in a clinical trial of ipilimumab and the anti-hormonal drug Lupron, Sharma, Allison and colleagues found that ipilimumab caused an immune response to the cancer reflected by major T cell penetration of tumors.They also found that PD-L1, a ligand that turns on the PD-1 checkpoint on T cells, was heavily expressed by the tumor and surrounding tissue in response, shutting down the T cell attack. Sharma and Allison hypothesized that combination treatment would induce an immune response with ipilimumab and then protect that response from deactivation by PD-1 with nivolumab.Sharma said investigators and sponsor Bristol-Myers Squibb are designing a follow-up trial that includes altering either the dosing or scheduling of ipilimumab with the goal of reducing side effects.Patients in the current trial, CheckMate-650, will be assessed for overall response rate and radiographic progression-free survival as primary endpoints and overall survival as a secondary endpoint.Allison has received royalties from Bristol-Myers in the past in connection with the development of ipilimumab but no longer receives such payments.
Reviewed by James Ives, M.Psych. (Editor)Mar 18 2019The arthroscopic superior capsule reconstruction (SCR) surgical technique offers patients with irreparable rotator cuff tears restored shoulder function and the opportunity to return to sports and physically-demanding work, according to research presented today at the AOSSM/AANA Specialty Day in Las Vegas, Nevada. The study, which examined patient outcomes up to five years after surgery, built upon earlier research which examined short-term patient results.”We studied 30 patients who were treated with arthroscopic SCR, and consistently saw improvements in outcomes related to shoulder function and the daily lives of those treated,” noted lead researcher Teruhisa Mihata, MD, PhD, from Osaka Medical College in Osaka, Japan. “The technique allowed 11 of 12 patients who had previously worked to return full-time at five-year follow-up, and all eight who had participated in sports to return to play.”Related StoriesAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyPenn Medicine and Grand View Health partner to provide advanced orthopedic careTen-fold rise in tongue-tie surgery for newborns ‘without any real strong data’The study measured both American Shoulder and Elbow Surgeons (ASES) and Japanese Orthopaedic Association (JOA) scores in patients, which improved significantly at both one and five years after surgery. The average ASES scores rose from 29.0 before surgery to 83.0 at one year and 92.3 at five years after surgery, with JOA scores rising from 51.5 before surgery to 85.9 and 91.4, respectively. Active elevation increased from 85 degrees prior to surgery to 151 degrees 5 years after the operation. Out of 30 patients followed for five years, only three (10%) experienced graft tears. Those who demonstrated graft healing also showed no sign of glenohumeral osteoarthritis during the five-year period.”Our latest research shows continued promise for the arthroscopic SCR technique, particularly to restore a patient’s shoulder function and allow them to return to work or sports if they so choose,” said Mihata. “We plan to continue studying longer-term outcomes for patients, focusing on continued function and the appearance of osteoarthritis.” Source:https://www.sportsmed.org/aossmimis/Members/About/Press_Releases/2019-Specialty-Day/Treating-Irreparable-Rotator-Cuffs-Injuries.aspx