Four policemen, including two sub-inspectors, were killed and seven others injured in an encounter with Maoists in Narayanpur district of south Chhattisgarh on Wednesday.“An encounter took place between the police and Maoists near Irapanar village in Abujhmad area of Narayanpur today. Two police sub-inspectors and two constables lost their lives [in the encounter]. Seven jawans were injured and are being brought to Raipur [for treatment],” Devnath, Additional Inspector General of the Anti-Naxal Operation (ANO) unit of Chhattisgarh police said.According to D. M. Awasthi, special Director General of Police in charge of the ANO, the encounter took place when the police team was venturing into the core Maoist area of Abujmad.Exchange of fire for over an hour“The operation was planned by Narayanpur SP [Superintendent of Police]. The police party left the base camp on Tuesday evening. The exchange of fire between the Maoists and the police team went on for over an hour,” he said.In another incident, two policemen suffered injuries in an IED (Improvised Explosive Device) explosion in Bijapur district of south Chhattisgarh.The IED, planted by Maoists, exploded when a police team was carrying out a search operation in Basaguda area of Bijapur. The injured policemen were evacuated to Raipur by a chopper.
Scores of students are expected to participate in the annual Youth Forum, scheduled for Friday (November 2) at the St. Andrew Parish Church Hall, 16 Ellesmere Road. The event, organised by the National Child Month Committee (NCMC), will get underway at 9:00 a.m. To be held under theme: ‘Jamaica 50: Let’s Celebrate Our Children,’ the forum will include presentations from the Wolmer’s Girls and Penwood High Schools on the topic:‘Care and Protection for our Children during the Past 50 years’, while St. George’s College and Ardenne High School will be looking at the topic: ‘Recognition and Celebration of the Achievements of Our Children during the Past 50 Years’. Minister of Youth and Culture, Hon. Lisa Hanna, is schedule to bring greetings, while Principal of Wolmer’s School for Girls, Colleen Montague, will be the guest speaker. The annual Youth Forum is one of several activities organised by the NCMC to mark Child Month. It provides an avenue for children to voice their views on issues that affect them. “Children should be encouraged to express their ideas about issues that affect them and the environment must be created for children to learn about their rights and responsibilities and also how to overcome challenges that impede their success,” said Chair of the NCMC, Dr. Pauline Mullings, in an interview with JIS News. Initially a Child Month activity in May, the Youth Forum was moved to November as the NCMC is committed to organising year-long activities geared towards the nation’s children as well as for the observance of National Youth Month. The NCMC, instituted in 1953, brings together a number of agencies working with and on behalf of children in an effort to focus on their needs, and heighten public awareness on the relevant issues affecting the nation’s children.
Source:https://www.mdanderson.org/newsroom/castration-resistant-prostate-cancer-responds-to-immunotherapy-combination.h00-159300678.html Reviewed by James Ives, M.Psych. (Editor)Feb 15 2019Two checkpoint inhibitors provide early encouraging results for immunologically cold diseaseSome patients with metastatic prostate cancer respond to a combination of immune checkpoint inhibitors after hormonal therapy and chemotherapy have failed, according to early results from a clinical trial led by investigators at The University of Texas MD Anderson Cancer Center presented today at the American Society of Clinical Oncology Genitourinary Cancers Symposium in San Francisco.Principal investigator Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology at MD Anderson, said the results of combining the CTLA-4 blocking drug ipilimumab with the PD-1 inhibitor nivolumab provide an encouraging step for a cancer that’s been highly resistant to immune checkpoint therapies.Research by Sharma and 2018 Nobel Laureate Jim Allison, Ph.D., chair of Immunology, leaders of MD Anderson’s immunotherapy platform, provided a rationale for combining the two drugs. The platform is part of MD Anderson’s Moon Shots Program™, a collaborative effort to accelerate the development of scientific discoveries into clinical advances that save patients’ lives.Among castration-resistant patients who had progressed after second-generation hormonal therapy (cohort 1), 25 percent (8 of 32) had their tumors shrink from the immunotherapy combination at a median follow-up of 11.9 months. Among those who progressed after chemotherapy and hormonal therapy (cohort 2) 10 percent (3 of 30) had a response at median follow-up of 13.5 months.”This was the first combination trial of two immune checkpoint therapies in prostate cancer,” Sharma said. “These results support the idea that immune checkpoint blockade can play an important role in the treatment of these patients and provide the foundation to test this strategy in a larger clinical trial.”There were four complete responders, two in each cohort, among the 62 patients who could be evaluated for tumor growth.Side effects from the combination were consistent with those experienced in previous combination trials for other cancers, with 42 percent of patients in cohort 1 and 53 percent in cohort 2 experiencing grade 3 to 5 adverse events. Among cohort 1, 33 percent had to discontinue participation due to adverse events, with 35.6 percent having to withdraw from cohort 2. The most common adverse events were diarrhea, fatigue, skin rash, nausea and hypothyroidism. Four patients died from treatment-related adverse events, two in each cohort.Related StoriesResearchers identify potential drug target for multiple cancer typesLiving with advanced breast cancerStudy reveals link between inflammatory diet and colorectal cancer riskDisease progression was the most common reason to leave the trial, with 51.1 percent of cohort 1 and 44.4 percent of cohort 2 discontinuing for that reason.The researchers also analyzed a number of biomarkers and found that higher tumor mutational burden was associated with response.Combination heats up cold tumorIn previous clinical trials, neither drug succeeded as single therapy against prostate cancer, a so-called “cold” malignancy because it does not attract the attention of the immune system. Few T cells, the adaptive immune system’s targeted warriors, infiltrate prostate tumors.In a phase I trial, no patients responded to nivolumab alone because the PD-1 inhibitor requires an immune response to be under way in order to attack tumors.The multi-center combination clinical trial by Bristol-Myers Squibb, maker of both drugs, was organized after research published in Nature Medicine by Sharma and Allison, provided scientific underpinning for the combination in prostate cancer.Analyzing tumor samples before and after treatment in a clinical trial of ipilimumab and the anti-hormonal drug Lupron, Sharma, Allison and colleagues found that ipilimumab caused an immune response to the cancer reflected by major T cell penetration of tumors.They also found that PD-L1, a ligand that turns on the PD-1 checkpoint on T cells, was heavily expressed by the tumor and surrounding tissue in response, shutting down the T cell attack. Sharma and Allison hypothesized that combination treatment would induce an immune response with ipilimumab and then protect that response from deactivation by PD-1 with nivolumab.Sharma said investigators and sponsor Bristol-Myers Squibb are designing a follow-up trial that includes altering either the dosing or scheduling of ipilimumab with the goal of reducing side effects.Patients in the current trial, CheckMate-650, will be assessed for overall response rate and radiographic progression-free survival as primary endpoints and overall survival as a secondary endpoint.Allison has received royalties from Bristol-Myers in the past in connection with the development of ipilimumab but no longer receives such payments.
Source:https://www.bfr.bund.de/ Reviewed by James Ives, M.Psych. (Editor)Apr 15 2019No third party may fundamentally publish the work of another without their consent. The BfR is therefore exercising its rights as a scientific institute.This procedure is independent of the scientific assessment. Addendum I has been published for years on the European Food Safety Authority (EFSA) website. All professionally qualified conclusions are therefore publicly accessible.Related StoriesPlant foods may transmit antibiotic-resistant superbugs to humansUnited Nations sounds alarm bell on drug-resistant infectionsNHS braces itself for more deaths following listeria outbreakMore openness and transparency in the assessment of active substances in plant protection products – that was the plea of BfR President Professor Dr Andreas Hensel at the hearing before the special committee of the EU Parliament on the approval of plant protection products last year. The BfR has been supporting the further improvement of the assessment procedures for years. The original toxicological studies prepared by industry should be freely accessible in the same way that the assessment reports published by EFSA already are. The existing laws should be complied with here, however.Unrestricted public access to scientific information is desirable in the view of the BfR. Glyphosate has been assessed as non-carcinogenic by the BfR in line with the latest available knowledge. This decision was reached on the basis of an independent, comprehensive assessment of all available scientific studies. After making their own assessments, all of the assessment authorities all over the world which had the original data at their disposal concluded that glyphosate should not be classified as carcinogenic to humans according to the latest available knowledge.
Kamaljit Kaur Sandhu New DelhiJuly 12, 2019UPDATED: July 12, 2019 17:51 IST Sources have said that the Kartarpur corridor structure on the Indian side will be completed by October 31. (India Today file photo)The Indian and the Pakistani officials will meet this Sunday for the second high-level talks on the Kartarpur Sahib corridor. The meeting is to find a way to iron out disagreements between the two countries. The Indian side is likely to reiterate the same set of concerns as the key issue remains unresolved — the construction of a causeway by Pakistan.While India is making a bridge for the pilgrims, the Pakistani side is constructing a “causeway”, which has been a persistent bone of contention between India and Pakistan on the Kartarpur corridor issue.India is of the view that not building a bridge would lead to flooding of the Indian areas during monsoon when the Ravi river overflows.”India has disagreed on the construction of a causeway. Causeways are not considered good engineering. India has been covering the Indian side of 68 km bund while the Pakistani side has a vast 250 km bund. Flooding in monsoon is a concern,” a government source said.The Indian team has suggested the use of “service road” by pilgrims till the time the bridge is not built by Pakistan.Kartarpur corridor structure on Indian side to be completed by October 31: SourcesA day after the Ministry of Home Affairs (MHA) sought to dismiss “misconceptions” that India has been slow in completing its side of the Kartarpur corridor, government sources have claimed that the construction on the Indian will be completed by October 31.The sources also said that the Indian government expects completion of the Kartarpur corridor on both the sides before the 550th birth anniversary of Guru Nanak Dev. Speaking to news agency ANI, a government source said, “Construction of the Kartarpur corridor on the Indian side will be completed by October 31. Sixty per cent is done. The government is keen that the Kartarpur corridor is completed on both the sides by the 550th anniversary of Guru Nanak Dev ji. India is looking forward to it with high expectation.”The movement of the Kartarpur corridor pilgrims is expected to be discussed in the meeting. Discussions on permits or visa-free access to all the pilgrims, fees and journey time of the pilgrims are also expected during the Kartarpur corridor talks.”India is creating an all-weather facility to cater to 10,000 pilgrims on special occasions and 5,000 pilgrims daily,” the source said, adding, “India will use high tech surveillance system and put a robust security system in place. That is not negotiable.”However, Pakistan wants to limit the number of pilgrims to 750 a day. Sources say that despite three technical meetings, the Pakistani side has not responded positively.Will reiterate concern regarding Khalistani terrorist Gopal Singh Chawla: SourcesThe government sources have said the Indian side will reiterate their concern regarding the Khalistani terrorist, Gopal Singh Chawla. Gopal Singh Chwala is linked to Sikh Gurdwara Parbandhak Committee and works in the capacity of its general secretary. He is known for his close links to Jama’at-ud-Da’wah (JuD) chief Hafiz Saeed.Also Read | India fully committed to Kartapur Sahib corridor, wants work to be completed expeditiously: MEAAlso Read | India proposes dates for Kartarpur corridor talks with PakistanAlso Watch | #5Reasons Why Pakistan says they decided to open Kartarpur Sahib corridorFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan Next Not a smooth road ahead for Kartarpur corridor amid India-Pak differences over constructionWhile India is making a bridge for the pilgrims, the Pakistani side is constructing a “causeway”, which has been a persistent bone of contention between India and Pakistan on the Kartarpur corridor issue. advertisement