2013 NSW Junior State Cup

first_imgwww.facebook.com/nswtouch And don’t forget to ‘like’ and ‘follow’ NSWTA their social media pages: The 2013 New South Wales Junior State Cup event is the first to be held in Port Macquarie, after having been played in Wollongong for the past 12 years. The Junior State Cup will be held in Port Macquarie for the next three events, from 2013-2015. New South Wales’ best junior Touch Football talent will be on display in Port Macquarie this weekend when they compete in the 2013 New South Wales Touch Association (NSWTA) Junior State Cup. Round games will be played on Saturday as well as Sunday morning, before finals are played on Sunday afternoon. www.twitter.com/nsw_touch www.nswtaevents.sportingpulse.net center_img Highlights of the event will be uploaded to the NSWTA YouTube channel, which can be found by clicking on the link below: www.youtube.com/nswta Related LinksNSW Junior State Cup Teams from across the state will compete in the following divisions – 10’s Boys and Girls, 12’s Boys and Girls, 14’s Boys and Girls, 16’s Boys and Girls and 18’s Boys and Girls. 288 teams will converge on the Port Macquarie Regional Sports Stadium and Tuffins Lane precinct for the event, coming from all areas across the state for the two day event, which will be played on Saturday, 16 February and Sunday, 17 February 2013. For all of the latest news and information in the lead up to and during the 2013 New South Wales Junior State Cup, please visit the NSWTA event website:last_img read more

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10 months agoMan Utd boss Solskjaer: Angel Gomes deserved chance

first_imgAbout the authorPaul VegasShare the loveHave your say Man Utd boss Solskjaer: Angel Gomes deserved chanceby Paul Vegas10 months agoSend to a friendShare the loveManchester United boss Ole Gunnar Solskjaer says Angel Gomes deserved his chance last week.Gomes featured in victory over Huddersfield.Solskjaer said, “It sends a signal to the boys that ‘you are close’, because they are. “They’ve done really well in training. When you get the chance to put a player out there for 15 minutes at Old Trafford to give him that experience, Angel was, of course, the one I wanted to put on. And we probably would have still done it if we’d needed a goal, as well, because he’s that sharp.” last_img

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Tech firms on alert as US top court takes up class action

first_imgGoogle Inc, Facebook Inc, eBay Inc and Yahoo Inc filed court papers backing Spokeo, a people search website. Image Credit: WashingtonPost Advertisement The U.S. Supreme Court will consider on Monday whether to nip in the bud a class action lawsuit against online search service Spokeo Inc in a case closely watched by Silicon Valley companies that face similar claims.If the court rules for Pasadena, California-based Spokeo and finds that a consumer lawsuit cannot proceed when the plaintiff cannot show he is being harmed, it could curtail a recent wave of class action cases against online companies.Google Inc, Facebook Inc, eBay Inc and Yahoo Inc filed court papers backing Spokeo, a people search website. – Advertisement – If similar cases are allowed to proceed against other companies, any user of their services who alleges a legal violation based only on a technical violation of a federal statute could “pursue a multi-billion dollar statutory damages claim despite the lack of injury,” the brief said.The case gives the conservative-leaning Supreme Court another chance to limit class action litigation as it has in a series of rulings including a major 2011 victory for Wal Mart Stores Inc.“We think this case presents the opportunity … to close the door on non-injury class actions,” said Jason Matthes, Spokeo’s general counsel.Facebook, Google and Yahoo have all faced similar lawsuits over violations of different federal laws. As many online companies have millions of users, a case can quickly snowball into a multimillion dollar class action.Without class action status, a case involving an individual plaintiff presents a much smaller risk to a company.Kate Todd, an attorney with the U.S. Chamber of Commerce’s legal arm, called the Spokeo dispute an example of plaintiffs’ lawyers “pushing the boundaries” of the types of cases that can be pursued.[related-posts]In the Spokeo case, plaintiff Thomas Robins sued in California on behalf of himself and a potential class under the Fair Credit Reporting Act, which requires consumer reporting agencies to provide correct information. There is a maximum $1,000 penalty per violation.Robins, who was unemployed when he sued in 2010, had claimed his Spokeo entry had damaged his job-seeking prospects because it contained inaccurate information. The entry, for example, said Robins has a graduate degree, which he called incorrect.“In today’s age, consumers are increasingly concerned about their online reputation,” said Robins’ attorney, Jay Edelson, whose firm specializes in suing tech companies for privacy violations.The high court is currently considering two other class action cases. One involving claims against advertising firm Campbell-Ewald Co was argued last month.The other, concerning a lawsuit against food producer Tyson Foods Inc, will be argued on Nov. 10.[Reuters]last_img read more

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Dark Data Research Reveals Widespread Complacency in Driving Business Results and Career

first_img AIDark DataDark Data ReportfundingMarketing TechnologyNewsSplunkTRUE Global Intelligence Previous ArticleThe Trade Desk Partners with Samba TV to Unify Digital and TV Media Strategies for the World’s Largest AdvertisersNext ArticlePimcore Launches Data Hub To Strengthen Content-As-A-Service Capabilities For Enhanced Data Delivery and Consumption Survey Finds New Skill Sets and AI to Be the Future; Organizations Not Turning Massive Data Opportunity into Meaningful Business OutcomesSplunk Inc., delivering actions and outcomes from the world of data, released research that shows organizations are ignoring potentially valuable data and don’t have the resources they need to take advantage of it. The research reveals that although business executives recognize the value of using all of their data, more than half (55 percent) of an organization’s total data is “dark data,” meaning they either don’t know it exists or don’t know how to find, prepare, analyze or use it.“the organization that has the most data is going to win.”The State of Dark Data Report, built using research conducted by TRUE Global Intelligence and directed by Splunk, surveyed more than 1,300 global business managers and IT leaders about how their organizations collect, manage and use data. In an era where data is connecting devices, systems and people at unprecedented growth rates, the results show that while data is top of mind, action is often far behind.76 percent of respondents surveyed across the US, UK, France, Germany, China, Japan, and Australia agree “the organization that has the most data is going to win.”60 percent of respondents said that more than half of their organizations’ data is dark, and one-third of respondents say more than 75 percent of their organization’s data is dark.Business leaders say their top three obstacles to recovering dark data is the volume of data, followed by the lack of necessary skill sets and resources.More than half (56 percent) admit that “data-driven” is just a slogan in their organization.82 percent say humans are and will always be at the heart of AI.Marketing Technology News: Snap Inc. Names Kenny Mitchell Chief Marketing Officer“Data is hard to work with because it’s growing at an alarming rate and is hard to structure and organize. So, it’s easy for organizations to feel helpless in this chaotic landscape,” says Tim Tully, chief technology officer, Splunk. “I was pleased to see the opportunity people around the world attach to dark data, even though fewer than a third of those surveyed say they have the skills to turn data into action. This presents a tremendous opportunity for motivated leaders, professionals and employers to learn new skills and reach a new level of results. Splunk can help those organizations feel empowered to take control of identifying and using dark data.”Respondents are Slow to Seize Career and Leadership OpportunitiesWhile respondents understand the value of dark data, they admit they don’t have the tools, expertise or staff to take advantage of it. Plus, the majority of senior leaders say they are close enough to retirement that they aren’t motivated to become data-literate. Data is the future of work, but only a small percentage of professionals seem to be taking it seriously. Respondents agree there is no single answer, though the top solutions having potential included training more employees in data science and analytics, increasing funding for data wrangling, and deploying software to enable less technical employees to analyze the data for themselves.92 percent say they are “willing” to learn new data skills but only 57 percent are “extremely” or “very” enthusiastic to work more with data.69 percent said they were content to keep doing what they’re doing, regardless of the impact on the business or their career.More than half of respondents (53 percent) said they are too old to learn new data skills when asked what they were doing to educate themselves and their teams.66 percent cite lack of support from senior leaders as a challenge in gathering data and roughly one-in-five respondents (21 percent) cite lack of interest from organization leaders as a challenge.Marketing Technology News: Factual Launches Measurement Intelligence to Track Real-World Conversions and Optimize Campaigns Across New and Emerging Digital ChannelsAI is Believed to Be The Next Frontier for Data-Savvy OrganizationsGlobally, respondents believe AI will generally augment opportunities, rather than replace people. While the survey revealed that few organizations are using AI right now, a majority see its vast potential. For example, in a series of use cases including operational efficiency, strategic decision making, HR and customer experience, only 10 to 15 percent say their organizations are deploying AI for these use cases while roughly two-thirds see the potential value.A majority of respondents (71 percent) saw potential in employing AI to analyze data.73 percent think AI can make up for the skills gaps in IT.82 percent say humans are and will always be at the heart of AI and 72 percent say that AI is just a tool to solve business problems.Only 12 percent are using AI to guide business strategy and 61 percent expect their organization to increase its use of AI this way over the next five years.Regional Differences Fuel Range of Opinions: China Furthest Ahead in Understanding the Potential of Dark DataThe research also discovered some distinct differences in attitude and opinion between the seven countries polled. For example, French, German and Japanese respondents seem less concerned about the value of data skills to their careers, with affirmative answers roughly 25 percent lower on average, than their counterparts in other countries. Respondents in China overwhelmingly voice the most enthusiasm and confidence in AI but their current adoption is only slightly higher than the global average. (20 to 16 percent)Marketing Technology News: Mobile Is Key to Boosting Guest Experiences Say HoteliersAustralian respondents implied the lowest AI adoption rates among all countries surveyed with 43 percent saying AI is already – or will in the near future be – an important part of their organizations’ operations compared to the global average of 52 percent.Although China leads response rates on the value and impact of AI across the research, 93 percent of Chinese respondents also believe machines can never replace human qualities like curiosity, creativity and initiative – the highest of any country.Only 64 percent of French respondents think data is a central component of an organization’s success compared to 81 percent globally.Only 58 percent of German leaders think data will grow more valuable over the next decade compared to 71 percent globally.Nearly four out of ten people in Japan (38 percent) say they are excited about working with data, lagging behind the global response of 57 percent.39 percent of people in the United Kingdom strongly believe AI can make up for the skills gap versus only 27 percent globally. Dark Data Research Reveals Widespread Complacency in Driving Business Results and Career Growth PRNewswireMay 2, 2019, 6:31 pmMay 2, 2019 last_img read more

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Importio Hires Industry Leaders to Meet Web Data Integration Market Expansion with

first_imgWeb Data Integration leader brings on tenured team leads to drive Import.io’s market share in burgeoning industryImport.io, the leading Web Data Integration solution provider, announced the hiring of three key team members to meet the demands of the rapidly expanding Web Data Integration market. The company brought on a new VP of engineering, VP of worldwide sales and a VP of delivery and managed services to drive annual recurring revenue (ARR) in this multi-billion-dollar market.Import.io hired Masa Karahashi as its new VP of engineering. Previously, Karahashi has led engineering efforts for a variety of start-ups, such as Human API, 3VR and Promptu. He has also spent more than a decade in various executive positions running worldwide enterprise engineering organizations at Oracle and Siebel where he was instrumental in ensuring the successful production launches of some of the world’s largest CRM deployments.Marketing Technology News: Flipboard Appoints Advertising Industry Veteran David Bell As New Board MemberDixon Fiske has joined the Import.io team as VP of worldwide sales. Fiske has been in technology sales for more than 30 years, most recently with SOASTA (acquired by Akamai), Boundary (acquired by BMC), and Nimsoft (acquired by CA Technologies). Now at his ninth startup, Fiske looks to continue his track record of building successful sales organizations and driving company growth.Kevin Zachary has joined Import.io as its new VP of delivery and managed services. Zachary previously led professional services and customer success at Cloudera.  Prior to joining Cloudera, Zachary spent 14 years at IBM where he led various strategic delivery initiatives focused on data management and emerging technologies for open source big data, machine learning, and AI.Marketing Technology News: Introducing Acoustic: A New Marketing Cloud Bringing Humanity to AI-Powered Marketing“The Web Data Integration market is growing exponentially and will require top industry talent to meet the heightened demand from customers,” said Gary Read, CEO of Import.io. “These roles are especially critical to fill with the expansion of our managed service business. We now have best-in-class sales leaders, a delivery team that can manage massive data projects and an engineering team that can streamline the development and delivery of vital WDI solutions that meet the needs of a demanding market.”“I’m looking forward to building a world-class sales organization here at Import.io to serve its billion-dollar market,” said Fiske. “We are transforming the way we do business to respond to prospect needs in an agile manner, expanding and closing deals quickly and efficiently. I’m eager to drive a companywide sales-focused culture to continue delivering solutions at scale.”Marketing Technology News: New TimeTrade Schedule-A-Demo Solution Helps B2B Software Companies Increase Inbound Lead-to-Meeting Conversion by 4X AIClouderacrmData Integration MarketGary ReadImport.ioNewsSales and Delivery Previous ArticleWalmart and Etsy Integrations Receive Major Upgrades in SureDone’s Multichannel E-Commerce PlatformNext ArticleRelationship Marketing Hub Optimove Hires New VP of R&D Import.io Hires Industry Leaders to Meet Web Data Integration Market Expansion with Enhanced Engineering, Sales and Delivery Globe Newswire5 days agoJuly 18, 2019 last_img read more

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Tellius and Snowflake Partner to Deliver CloudNative Augmented Analytics at Scale

first_imgTellius and Snowflake Customers Benefit from Modern AI-Powered Analytics Leveraging the Data Warehouse Built for the CloudTellius, a leading provider of AI-powered augmented analytics software, today announced a partnership with Snowflake, Inc, the data warehouse built for the cloud. Through the partnership, the Tellius Search and AI-Powered Analytics platform is certified to natively connect to the Snowflake data warehouse, allowing customers to discover insights at scale without worrying about analytics performance.Organizations leverage Tellius as a fast, simplified, and collaborative approach for business users, data analysts, citizen data scientists, and data engineers to visualize enterprise data using natural language and voice, discover insights assisted by AI, and automate machine learning across all their business data.“With our partners at Snowflake, we are delivering cloud-native data analytics to accelerate business impact from AI and machine learning,” said Ajay Khanna, Founder and CEO of Tellius. “Business users and data professionals can now focus on deriving insights across their multiple data sources and enterprise applications and on taking action based on automated recommendations without compromising on analytics performance.”The Snowflake Data Warehouse is a modern cloud data-warehouse-as-a-service offering. Snowflake’s ability to analyze data from diverse sources along with automatic tuning and scaling removes the headache of monitoring and fine-tuning data warehouse manually. By integrating Tellius natively with Snowflake, users can now get exceptional performance on data insights of any scale without worrying about maintaining the data warehouse infrastructure.“Our customers need cutting-edge analytics to get meaningful insights to their critical data questions,” said Hardik Chheda, Head of Product at Tellius. “With our integration with Snowflake, they can now build modern business intelligence and predictive analytics applications at scale.”Tellius + Snowflake advantages:In-database Augmented Analytics – Analyze petabytes of live data securely without moving it out of Snowflake’s data warehouse.Insights Across Data Sources – Discover insights from a multitude of sources on Snowflake data warehouse by analyzing disparate structured and unstructured data.Blazing Fast Data Collaboration – Democratize data access across your analytics team without any worrying about performance or IT maintenance.Tellius for Snowflake is now available. To learn more, schedule a demonstration of the Tellius Search and AI-Powered Analytics Platform. Tellius and Snowflake Partner to Deliver Cloud-Native Augmented Analytics at Scale PRNewswire4 days agoJuly 22, 2019 Augmented AnalyticscloudNewsSnowflakeTellius Previous ArticleThe Wild Releases Oculus Quest Support, Opening The Door To Team-Wide VR Collaboration For Architecture and DesignNext ArticleDods Group Plc Acquires Meritgroup Limited, a B2B Data and Technology Specialistlast_img read more

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PAC1R mutation in children with autism may be linked to severity of

first_imgRelated StoriesNew gene-editing protocol allows perfect mutation-effect matchingTransgenerational BPA exposure may contribute to autism, study findsProblem behaviors may provide clues on gastrointestinal issues in children with autismAll told, the project is the fruit of six years of painstaking research and data collection, say the researchers. That includes banking patients’ saliva samples collected during clinical visits for future retrospective analyses to determine which genetic mutations were correlated with behavioral and functional brain deficits, Corbin adds.”Lauren Kenworthy, who directs our Center for Autism Spectrum Disorders, and I have been talking over the years about how we could bring our programs together. We homed in on this project to look at about a dozen genes to assess correlations and brought in experts from genetics and genomics at Children’s National to sequence genes of interest,” he adds. “Linking the bench to bedside is especially difficult in neuroscience. It takes a huge amount of effort and dozens of discussions, and it’s very rare. It’s an exemplar of what we strive for.” Reviewed by James Ives, M.Psych. (Editor)Jan 8 2019A mutation of the gene PAC1R may be linked to the severity of social deficits experienced by kids with autism spectrum disorder (ASD), finds a study from a multi-institutional research team led by Children’s faculty. If the pilot findings are corroborated in larger, multi-center studies, the research published online Dec. 17, 2018, in Autism Research represents the first step toward identifying a potential novel biomarker to guide interventions and better predict outcomes for children with autism.As many as 1 in 40 children are affected by ASD. Symptoms of the disorder – such as not making eye contact, not responding to one’s name when called, an inability to follow a conversation of more than one speaker or incessantly repeating certain words or phrases – usually crop up by the time a child turns 3.The developmental disorder is believed to be linked, in part, to disrupted circuitry within the amygdala, a brain structure integral for processing social-emotional information. This study reveals that PAC1R is expressed during key periods of brain development when the amygdala – an almond-shaped cluster of neurons – develops and matures. A properly functioning amygdala, along with brain structures like the prefrontal cortex and cerebellum, are crucial to neurotypical social-emotional processing.”Our study suggests that an individual with autism who is carrying a mutation in PAC1R may have a greater chance of more severe social problems and disrupted functional brain connectivity with the amygdala,” says Joshua G. Corbin, Ph.D., interim director of the Center for Neuroscience Research at Children’s National Health System and the study’s co-senior author. “Our study is one important step along the pathway to developing new biomarkers for autism spectrum disorder and, hopefully, predicting patients’ outcomes.”The research team’s insights came through investigating multiple lines of evidence: Source:https://childrensnational.org/center_img They looked at gene expression in the brains of an experimental model at days 13.5 and 18.5 of fetal development and day 7 of life, dates that correspond with early, mid and late amygdala development. They confirmed that Pac1r is expressed in the experimental model at a critical time frame for brain development that coincides with the timing for altered brain trajectories with ASD. They looked at gene expression in the human brain by mining publicly available genome-wide transcriptome data, plotting median PAC1R expression values for key brain regions. They found high levels of PAC1R expression at multiple ages with higher PAC1R expression in male brains during the fetal period and higher PAC1R expression in female brains during childhood and early adulthood. One hundred twenty-nine patients with ASD aged 6 to 14 were recruited for behavioral assessment. Of the 48 patients who also participated in neuroimaging, 20 were able to stay awake for five minutes without too much movement as the resting state functional magnetic resonance images were captured. Children who were carriers of the high-risk genotype had higher resting-state connectivity between the amygdala and right posterior temporal gyrus. Connectivity alterations in a region of the brain involved in processing visual motion may influence how kids with ASD perceive socially meaningful information, the authors write. Each child also submitted a saliva sample for DNA genotyping. Previously published research finds that a G to C single nucleotide polymorphism, a single swap in the nucleotides that make up DNA, in PAC1R is associated with higher risk for post-traumatic stress disorder in girls. In this behavioral assessment, the research team found children with autism who carried the homozygous CC genotype had higher scores as measured through a validated tool, meaning they had greater social deficits than kids with the heterozygous genotype.last_img read more

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Castrationresistant metastatic prostate cancer responds to combination of immune checkpoint inhibitors

first_img Source:https://www.mdanderson.org/newsroom/castration-resistant-prostate-cancer-responds-to-immunotherapy-combination.h00-159300678.html Reviewed by James Ives, M.Psych. (Editor)Feb 15 2019Two checkpoint inhibitors provide early encouraging results for immunologically cold diseaseSome patients with metastatic prostate cancer respond to a combination of immune checkpoint inhibitors after hormonal therapy and chemotherapy have failed, according to early results from a clinical trial led by investigators at The University of Texas MD Anderson Cancer Center presented today at the American Society of Clinical Oncology Genitourinary Cancers Symposium in San Francisco.Principal investigator Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology at MD Anderson, said the results of combining the CTLA-4 blocking drug ipilimumab with the PD-1 inhibitor nivolumab provide an encouraging step for a cancer that’s been highly resistant to immune checkpoint therapies.Research by Sharma and 2018 Nobel Laureate Jim Allison, Ph.D., chair of Immunology, leaders of MD Anderson’s immunotherapy platform, provided a rationale for combining the two drugs. The platform is part of MD Anderson’s Moon Shots Program™, a collaborative effort to accelerate the development of scientific discoveries into clinical advances that save patients’ lives.Among castration-resistant patients who had progressed after second-generation hormonal therapy (cohort 1), 25 percent (8 of 32) had their tumors shrink from the immunotherapy combination at a median follow-up of 11.9 months. Among those who progressed after chemotherapy and hormonal therapy (cohort 2) 10 percent (3 of 30) had a response at median follow-up of 13.5 months.”This was the first combination trial of two immune checkpoint therapies in prostate cancer,” Sharma said. “These results support the idea that immune checkpoint blockade can play an important role in the treatment of these patients and provide the foundation to test this strategy in a larger clinical trial.”There were four complete responders, two in each cohort, among the 62 patients who could be evaluated for tumor growth.Side effects from the combination were consistent with those experienced in previous combination trials for other cancers, with 42 percent of patients in cohort 1 and 53 percent in cohort 2 experiencing grade 3 to 5 adverse events. Among cohort 1, 33 percent had to discontinue participation due to adverse events, with 35.6 percent having to withdraw from cohort 2. The most common adverse events were diarrhea, fatigue, skin rash, nausea and hypothyroidism. Four patients died from treatment-related adverse events, two in each cohort.Related StoriesResearchers identify potential drug target for multiple cancer typesLiving with advanced breast cancerStudy reveals link between inflammatory diet and colorectal cancer riskDisease progression was the most common reason to leave the trial, with 51.1 percent of cohort 1 and 44.4 percent of cohort 2 discontinuing for that reason.The researchers also analyzed a number of biomarkers and found that higher tumor mutational burden was associated with response.Combination heats up cold tumorIn previous clinical trials, neither drug succeeded as single therapy against prostate cancer, a so-called “cold” malignancy because it does not attract the attention of the immune system. Few T cells, the adaptive immune system’s targeted warriors, infiltrate prostate tumors.In a phase I trial, no patients responded to nivolumab alone because the PD-1 inhibitor requires an immune response to be under way in order to attack tumors.The multi-center combination clinical trial by Bristol-Myers Squibb, maker of both drugs, was organized after research published in Nature Medicine by Sharma and Allison, provided scientific underpinning for the combination in prostate cancer.Analyzing tumor samples before and after treatment in a clinical trial of ipilimumab and the anti-hormonal drug Lupron, Sharma, Allison and colleagues found that ipilimumab caused an immune response to the cancer reflected by major T cell penetration of tumors.They also found that PD-L1, a ligand that turns on the PD-1 checkpoint on T cells, was heavily expressed by the tumor and surrounding tissue in response, shutting down the T cell attack. Sharma and Allison hypothesized that combination treatment would induce an immune response with ipilimumab and then protect that response from deactivation by PD-1 with nivolumab.Sharma said investigators and sponsor Bristol-Myers Squibb are designing a follow-up trial that includes altering either the dosing or scheduling of ipilimumab with the goal of reducing side effects.Patients in the current trial, CheckMate-650, will be assessed for overall response rate and radiographic progression-free survival as primary endpoints and overall survival as a secondary endpoint.Allison has received royalties from Bristol-Myers in the past in connection with the development of ipilimumab but no longer receives such payments.last_img read more

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First Global Forum of Face Equality International takes place in London

first_imgMar 12 2019The first Global Forum of the new alliance, Face Equality International, is taking place this week, 12th-14th March in central London. Representatives of 19 NGOs and charities have traveled from around the world to take part — to discuss how best to promote face equality and stamp out disfigurement discrimination wherever it happens. The delegations include leaders of the nine ‘founding NGOs’ such as the Sunshine Welfare Foundation in Taiwan, Smile Train, the Phoenix Society for Burn Survivors and FACES in the US, the European Cleft Organization in the Netherlands, the Smile Foundation in South Africa and Changing Faces in the UK. They will be joined by some of the 18 NGOs that have joined Face Equality International since it was launched just four months ago.  Related StoriesSolid fuel use linked with increased risk of hospitalization or death from respiratory diseasesWhat’s the best time of the day to lose weight?Loose double-stranded RNA molecules spur skin rejuvenationFace Equality International is the brainchild of Dr James Partridge OBE, the founder and former CEO of the UK charity Changing Faces. He says that disfigurement is a neglected global human rights issue: “Wherever they live in the world, people with disfigurements — whether from cleft lips and palates, birthmarks, burns, acid violence, facial paralysis like Bell’s palsy, skin conditions such as psoriasis and vitiligo or after facial cancer — have to deal with many psychological, social and economic challenges in living confident, successful lives in the 21st century”.  “All the Members know from their clients/users that having a facial difference can mean someone is isolated and friendless, facing bullying, ridicule and staring in public, low expectations in school, problems getting work and harassment in the workplace, abuse on social media and stereotyping in the media. The unexpected but encouraging growth in membership in the three months since our launch shows the need for our organization”.Face Equality International will challenge such unfairness and discrimination by mobilizing NGOs around the world and sharing the lessons of how to advocate for face equality effectively — such as awareness-raising initiatives with teachers, culture and business people, and ripostes to everyday incidents of facial prejudice in the media. The alliance will also campaign for people with disfigurements around the world to be properly protected by law from facial discrimination in workplaces, on social media, in schools or public places.Topics to be debated at the Global Forum include how to best challenge social media abuse and influence the attitudes of the public and the media, and how to prepare teachers to create inclusive education and to meet the targets laid down in the UN’s Sustainable Development Goals. The Forum will also be the first opportunity for Members to explore how the work together effectively. Source:https://faceequalityinternational.org/news/media-release-12-mar-19/last_img read more

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Study reveals another surgical option for patients with irreparable rotator cuff tears

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 18 2019The arthroscopic superior capsule reconstruction (SCR) surgical technique offers patients with irreparable rotator cuff tears restored shoulder function and the opportunity to return to sports and physically-demanding work, according to research presented today at the AOSSM/AANA Specialty Day in Las Vegas, Nevada. The study, which examined patient outcomes up to five years after surgery, built upon earlier research which examined short-term patient results.”We studied 30 patients who were treated with arthroscopic SCR, and consistently saw improvements in outcomes related to shoulder function and the daily lives of those treated,” noted lead researcher Teruhisa Mihata, MD, PhD, from Osaka Medical College in Osaka, Japan. “The technique allowed 11 of 12 patients who had previously worked to return full-time at five-year follow-up, and all eight who had participated in sports to return to play.”Related StoriesAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyPenn Medicine and Grand View Health partner to provide advanced orthopedic careTen-fold rise in tongue-tie surgery for newborns ‘without any real strong data’The study measured both American Shoulder and Elbow Surgeons (ASES) and Japanese Orthopaedic Association (JOA) scores in patients, which improved significantly at both one and five years after surgery. The average ASES scores rose from 29.0 before surgery to 83.0 at one year and 92.3 at five years after surgery, with JOA scores rising from 51.5 before surgery to 85.9 and 91.4, respectively. Active elevation increased from 85 degrees prior to surgery to 151 degrees 5 years after the operation. Out of 30 patients followed for five years, only three (10%) experienced graft tears. Those who demonstrated graft healing also showed no sign of glenohumeral osteoarthritis during the five-year period.”Our latest research shows continued promise for the arthroscopic SCR technique, particularly to restore a patient’s shoulder function and allow them to return to work or sports if they so choose,” said Mihata. “We plan to continue studying longer-term outcomes for patients, focusing on continued function and the appearance of osteoarthritis.” Source:https://www.sportsmed.org/aossmimis/Members/About/Press_Releases/2019-Specialty-Day/Treating-Irreparable-Rotator-Cuffs-Injuries.aspxlast_img read more

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Study Pathogenetic downregulation of adenosine linked to restless leg syndrome

first_img Source:https://home.liebertpub.com/news/is-adenosine-the-missing-link-in-restless-leg-syndrome/3534 Reviewed by James Ives, M.Psych. (Editor)Apr 4 2019Researchers have identified a common mechanism implicating adenosine in the cause of restless leg syndrome (RLS) symptoms — the periodic limb movements characteristic of RLS and the state of enhanced arousal that both disrupt sleep. Preclinical findings in a rat model of RLS and clinical results in humans together suggest that targeting the pathogenetic downregulation of adenosine A1 receptor (A1R) may be a promising therapeutic strategy, according to an editorial published in Journal of Caffeine and Adenosine Research, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Journal of Caffeine and Adenosine Research website until May 3, 2019.Related StoriesAn active brain and body associated with reduced risk of dementiaNeural pathways explain the relationship between imagination and willingness to helpStudy offers clues about how to prevent brain inflammation in Alzheimer’sRLS is a common disorder, with about 5% of individuals in the U.S. and Europe reporting symptoms, as described in the article “The Adenosine Hypothesis of Restless Legs Syndrome”. More than one pathogenetic mechanism likely underlies the spinal cord-related and non-spinal cord-related aspects of the disorder, and researchers have long looked for a biochemical link that could serve as a new therapeutic target. A combination of preclinical and clinical findings has shown that brain iron deficiency (BID) is an early factor in the pathophysiology of RLS and that BID in rodents causes downregulation of A1Rs in the brain.”Based on these results,” Editor-in-Chief of Journal of Caffeine and Adenosine Research, Sergi Ferré, MD, PhD, and his research colleagues in the Integrative Neurobiology Section, National Institute on Drug Abuse, National Institutes of Health (Baltimore, MD), “have hypothesized that a hypoadenosinergic state secondary to A1R downregulation could be mostly responsible for the hyperglutamatergic and hyperdopaminergic states of RLS that determine the sensorimotor symptoms of RLS as well as the hyperarousal component.” They add, “We, therefore, predicted that inhibitors of equilibrative nucleoside transporters, by increasing the striatal extra-cellular levels of adenosine, could provide a new therapeutic approach for RLS.”last_img read more

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Canada Apple back development of carbonfree aluminum smelting tech

Canada and Quebec province, as well as tech giant Apple, announced Thursday their backing of aluminum producers Alcoa and Rio Tinto’s new joint venture to develop a carbon-free smelting process. Citation: Canada, Apple back development of carbon-free aluminum smelting tech (2018, May 10) retrieved 18 July 2019 from https://phys.org/news/2018-05-canada-apple-carbon-free-aluminum-smelting.html © 2018 AFP Aluminum is used in everything from cars and planes, softdrink cans, foil and window frames, as well as in Apple smartphones, tablets and computers Toyota invests Can$1.4 billion in Canada plants This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Prime Minister Justin Trudeau made the announcement with executives of the three companies on hand.Apple is investing Can$13 million (US$10 million) in the joint venture, and will provide technical support.Rio and Alcoa are investing Can$55 million (US$43 million), while the Canadian and Quebec governments will each invest Can$60 million (US$47 million) in a first round of financing.The technology promises to be “the most significant innovation in the aluminum industry in more than a century, and marks a decisive step forward in the fight against climate change,” said a statement.”Once fully developed and implemented, the ground-breaking technology will virtually eliminate the Canadian aluminum industry’s carbon footprint.”Aluminum is used in everything from cars and planes, softdrink cans, foil and window frames, as well as in Apple smartphones, tablets and computers.The sector employs 10,500 people in Canada.Alcoa is the largest aluminum producer in the United States and Rio is the world’s second-largest miner.Their joint venture is to be named Elysis and headed by Rio executive Vincent Christ. It will be based in Montreal, with a research facility in Quebec’s Saguenay region.The new technology is expected to be ready for licensing to retrofit smelters or build new facilities by 2024.According to Ottawa, it has the potential to reduce annual greenhouse gas emissions by approximately 6.5 million metric tonnes in Canada—the equivalent of taking 1.8 million cars off the road.”We are proud to be part of this ambitious new project, and look forward to one day being able to use aluminum produced without direct greenhouse gas emissions in the manufacturing of our products,” Apple chief executive Tim Cook said in the statement. Explore further read more

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Movies are as popular as ever but rising ticket prices may be

first_imgFans queue to see Avengers: Endgame in Bangkok. Credit: CCCCi12 via Shutterstock This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. This article is republished from The Conversation under a Creative Commons license. Read the original article. Why does this matter? At a time when few places offer everyone in society the opportunity to access a shared human experience – to laugh and cry at the same things in the same shared space – it is of paramount importance that cinema remains affordable to all.Social significanceIt is not a matter of cultural significance but of social significance. When Steven Spielberg says that “there’s nothing like going to a big dark theatre with people you’ve never met before and having the experience wash over you”, he’s not making an argument about the superior artistic stature of cinema – to prioritise one art form over another is absurd. Filmmakers like Spielberg remind us that going to the cinema has, over the course of the past century, become a right of everybody to participate in the cultural life of the nation.Historically, cinema achieved this crucial role as a cultural and social meeting-point by being affordable to all – ensuring that the most diverse cross-section of the population could afford to go to the cinema regularly. In this sense, it is fundamentally different to television or video games, because going to the cinema is a cultural practice that requires a social contract between the audience, the exhibitors and the filmmakers – where you agree to leave the house, sit in a dark theatre and share the film experience with people you don’t know.This may sound strange, but seeing a movie and going to the cinema are two different things. Going to the cinema requires a level of commitment that is fundamentally different to choosing to sit down and watch television or play with a games console at home.It’s not about the artistic quality of the medium – but of democratic participation and the consequences of increasing levels of division in society. At its core, film is proven to have a shared emotional, artistic experience – not just with friends, but with strangers and, crucially, in a public space which, at least for those two hours, belongs to everyone.For the manyWhile there is no easy fix to this issue, sliding price scales based on income and other related factors, to name one particularly intriguing way of rethinking prices that has already proved to be successful where trialled, may provide a useful starting point for the conversation.This is a tale with no obvious villain – cinema owners invest huge amounts of money every year in upgrades while studios spend many millions making the movies they believe people want to see. For this story to have a happy ending it is therefore crucial to ensure that the conversation does not get stuck in the kind of simplifications (film versus Netflix, distributors versus audiences) that may make for good headlines but mask the real risks we all run if cinema should become a pastime for the few.So ensuring access to the cinema experience for everyone should be part of the political and social conversation – not just an issue of preference. Streaming is not the enemy in this picture, but allowing significant cross-sections of the cinema-going population to be cut off from the most popular form of cultural engagement, most definitely is. Explore further Citation: Movies are as popular as ever, but rising ticket prices may be shutting many people out of the cinema (2019, May 9) retrieved 17 July 2019 from https://phys.org/news/2019-05-movies-popular-ticket-prices-people.htmlcenter_img Against increasingly tougher odds, cinema-going remains the most popular form of cultural participation and public social engagement – and it is the same story pretty much wherever you look around the world.Behind this success story, though, lies a serious threat. Despite billions of tickets sold every year worldwide and box office revenue steadily increasing since the 1970s (reaching over US$40 billion in 2018) these numbers mask a gradual narrowing of the socioeconomic spectrum of cinema-going audiences.If the trend of increasing ticket prices and the business models that underpin this increase continue, this staple form of public participation and communal engagement will lose its social function. Rising ticket prices will effectively exclude many of those for whom cinema was intended in the first place, resulting in its complete gentrification.Rising pricesAs part of my research, I calculated the relative cost of movie tickets over the years and compared that with wages. It paints a bleak picture. Adjusted for inflation to give a contemporary perspective, attending a movie theatre in 1938 in the US (the year the Fair Labor Standards Act established the federal minimum hourly wage) cost the equivalent of US$4.14 (calculated by adjusting the original ticket price to January 2019 prices. That meant that for every hour worked at minimum wage – then set at US$5.39 – film-goers would invest roughly 75% of one hour’s work. In 2018, going to the cinema cost US$9.11 – so a minimum wage worker would need to invest 125% of their hourly wage to buy a cinema ticket. US minimum hourly wage has been stuck at US$7.25 since 2009.In the UK, the situation is only marginally better. Cinema prices average £7.22 (US$9.40) against a minimum wage set at £7.83 (US$10.20) for over-25s – but dropping rapidly for those below that age to as low as £5.90 (US$7.70) for 18- to 20-year-olds. The Ultimate Home Cinematic 21:9 Viewing Experience Provided by The Conversation The UK cinema association announced late in 2018 that movie admissions were on course to hit 176m for the year, 6m more than in 2017 and the highest since the 1970s when blockbusters such as Star Wars and Jaws had people queuing round the block. This in an era of streaming, online sharing platforms and on-demand, on-the-go access to virtually any film, anywhere.last_img read more

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Not a smooth road ahead for Kartarpur corridor amid IndiaPak differences over

first_img Kamaljit Kaur Sandhu New DelhiJuly 12, 2019UPDATED: July 12, 2019 17:51 IST Sources have said that the Kartarpur corridor structure on the Indian side will be completed by October 31. (India Today file photo)The Indian and the Pakistani officials will meet this Sunday for the second high-level talks on the Kartarpur Sahib corridor. The meeting is to find a way to iron out disagreements between the two countries. The Indian side is likely to reiterate the same set of concerns as the key issue remains unresolved — the construction of a causeway by Pakistan.While India is making a bridge for the pilgrims, the Pakistani side is constructing a “causeway”, which has been a persistent bone of contention between India and Pakistan on the Kartarpur corridor issue.India is of the view that not building a bridge would lead to flooding of the Indian areas during monsoon when the Ravi river overflows.”India has disagreed on the construction of a causeway. Causeways are not considered good engineering. India has been covering the Indian side of 68 km bund while the Pakistani side has a vast 250 km bund. Flooding in monsoon is a concern,” a government source said.The Indian team has suggested the use of “service road” by pilgrims till the time the bridge is not built by Pakistan.Kartarpur corridor structure on Indian side to be completed by October 31: SourcesA day after the Ministry of Home Affairs (MHA) sought to dismiss “misconceptions” that India has been slow in completing its side of the Kartarpur corridor, government sources have claimed that the construction on the Indian will be completed by October 31.The sources also said that the Indian government expects completion of the Kartarpur corridor on both the sides before the 550th birth anniversary of Guru Nanak Dev. Speaking to news agency ANI, a government source said, “Construction of the Kartarpur corridor on the Indian side will be completed by October 31. Sixty per cent is done. The government is keen that the Kartarpur corridor is completed on both the sides by the 550th anniversary of Guru Nanak Dev ji. India is looking forward to it with high expectation.”The movement of the Kartarpur corridor pilgrims is expected to be discussed in the meeting. Discussions on permits or visa-free access to all the pilgrims, fees and journey time of the pilgrims are also expected during the Kartarpur corridor talks.”India is creating an all-weather facility to cater to 10,000 pilgrims on special occasions and 5,000 pilgrims daily,” the source said, adding, “India will use high tech surveillance system and put a robust security system in place. That is not negotiable.”However, Pakistan wants to limit the number of pilgrims to 750 a day. Sources say that despite three technical meetings, the Pakistani side has not responded positively.Will reiterate concern regarding Khalistani terrorist Gopal Singh Chawla: SourcesThe government sources have said the Indian side will reiterate their concern regarding the Khalistani terrorist, Gopal Singh Chawla. Gopal Singh Chwala is linked to Sikh Gurdwara Parbandhak Committee and works in the capacity of its general secretary. He is known for his close links to Jama’at-ud-Da’wah (JuD) chief Hafiz Saeed.Also Read | India fully committed to Kartapur Sahib corridor, wants work to be completed expeditiously: MEAAlso Read | India proposes dates for Kartarpur corridor talks with PakistanAlso Watch | #5Reasons Why Pakistan says they decided to open Kartarpur Sahib corridorFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan Next Not a smooth road ahead for Kartarpur corridor amid India-Pak differences over constructionWhile India is making a bridge for the pilgrims, the Pakistani side is constructing a “causeway”, which has been a persistent bone of contention between India and Pakistan on the Kartarpur corridor issue. advertisementlast_img read more

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