Story Links PDF Box Score Postgame Quotes Listen Live CBS Matchup History Postgame Notes Next Game: vs. Minnesota 3/21/2019 | Preview CHARLOTTE, N.C. (AP) — Luke Maye had 19 points and nine rebounds, Coby White added 17 points, seven rebounds and six assists – and committed just one turnover – and North Carolina beat Louisville 83-70 on Thursday night in the Atlantic Coast Conference quarterfinals.”I’m trying to make the easy play,” White said. ”I’m trying not to force it.”White’s controlled play has the second-seeded Tar Heels in line for a run at their second ACC Tournament championship in four years and a No. 1 seed in the NCAA Tournament.”I get on him about his shots and I get on him about his turnovers,” Williams said. ”But he is making much better decisions. It’s attack, attack, attack. That’s what we talk about all the time. We want to attack like crazy and be under control.”Maye was stellar as he has been for most of his career with the Tar Heels, taking over on the glass in the second half and scoring from all three levels on offense – attacking the basket, knocking down mid-range jumpers and stroking 3-pointers.Cameron Johnson chipped in with 14 points – all in the first half – to help the Tar Heels (27-5) extend their winning streak to eight games.Dwayne Sutton had 14 points for Louisville (20-13).The Cardinals beat North Carolina by 19 on Jan. 12 in Chapel Hill – Williams’ worst home loss ever as Tar Heels coach – using their size and length to disrupt shooters and control the glass.North Carolina had no trouble in the rubber match between the teams.The Tar Heels built a 45-35 lead at the half behind Johnson and White, who got the basket with ease. But the lead hovered around 10 for most of the second half until the Tar Heels got their transition game going with eight straight points on run outs – including four by Kenny Williams – to stretch the lead to 18 with 6:24 left.Louisville coach Chris Mack called North Carolina’s transition game ”phenomenal.””They are as fast as any team I’ve coached against,” Mack said. ”And you talk about it, you talk about it, but talking doesn’t prepare you sometimes. And you give those guys credit, they were shot out of a cannon, that ball was up the floor and in such a hurry and got to the rim.”AVENGING LOSSMaye, who grew up in the Charlotte suburb of Huntersville, was excited to get a win in his return home especially after the Tar Heels lost here in the second round of the NCAA Tournament to Texas A&M.”I love coming back to Charlotte and this was a big win for us,” Maye said.WELL PREPAREDMack believes the Cardinals are well prepared for the NCAA Tournament after competing in the ACC with three teams ranked in the top five in the country.”I told these guys in the locker room that we have played the best teams in the country,” Mack said. ”I mean there’s a reason that y’all are talking about a possibility, not saying it’s going to happen, a possibility of three No. 1 seeds. That’s incredible. … It’s the best conference in the country, in my opinion.”BIG PICTURELouisville: Despite the loss, the Cardinals appear to have a good chance to get an at-large berth in the NCAA Tournament as a 20-win team in a tough conference.North Carolina: The Tar Heels arrived in Charlotte chasing a No. 1 seed in the NCAA Tournament and if they continue to play like this over the next two days they’ll be a lock to get one.UP NEXTLouisville: Will await word on an NCAA Tournament bid.North Carolina: Will face the winner Duke-Syracuse winner in the semifinals Friday night. Full Schedule Roster Game Highlights Photo Gallery Print Friendly Version
Asmodeus1/13Dungeons & Dragons cosmology gets hella confusing, wicked fast. It makes the Silmarillion look straight forward. It’s that nutso, especially when you take into account multiple campaign settings across multiple editions in multiple decades. But still, with all that, we were able to pick a favorite fake Satan from the world of D&D and it’s none other than Asmodeus. How badass is Asmodeus? The dude started as the creation of a bunch of angels, and then ended up creating his own plane of existence: The Nine Layers of Hell.<><> Going back about as far as anyone cares to – maybe even further – Satan, Lucifer, The Devil has been a massive part of literature and pop culture. Hell, he’s the Big Bad in the Bible! The Bible! But in more recent decades, there’s been an interesting trend for writers and creators to use not The Devil, but just a devil. But not just some generic rank-and-file demon – no, these fake Satans are basically The Devil. It’s just, for one reason or another… they aren’t.Collected here are the best examples of this concept, plus some that we just shoe-horned in because we like them.Note: If there’s a Harambe slide in here, please don’t blame me. Those jokes make me sad and my editors like seeing me suffer. They’re sadistic monsters. THEY should be on this list. Not Harambe. [Editor’s Note: It’s true, we have been honoring Harambe as a smart ape, dank wizard, potential Pokemon, and quiet karate-man. We do not regret our actions. However, we agree that the beloved ape is definitely not a fake Satan] We could have made this list twice as long. Or six times as long! Or, wait, we got it, 666 times as long? Hahahaha, right? Anyway, tell us your favorite fake Satans down in the comments below. Or don’t. Your call.Aubrey Sitterson is the creator of the ongoing sword & sorcery serial podcast, SKALD. It doesn’t have one specific devil in it, but it does have more than its fair share of a nefarious elder god. You should check it out on iTunes, Google Play, Stitcher & Podomatic. Follow Aubrey on Twitter or check out his website for more information.
Explore further (PhysOrg.com) — With its unique double-helical structure, DNA has the ability to be used as a programmable building material to construct designer nanoscale architectures. Complex DNA architectures could have a variety of applications, from DNA-based nanomotors to biosensing and drug delivery. Taking the research a step forward, researchers have recently constructed a nanometer-sized tetrahedron from a single strand of DNA, using a method that could have advantages for assembling similar structures on a large scale. Front and top views of the 3D molecular model of the tetrahedron. Image copyright: Zhe Li, et al. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The researchers, from Arizona State University (ASU) and the Hong Kong University of Science and Technology (HKUST), have published their results in a recent issue of the Journal of the American Chemical Society. As the researchers explain, the variety of different artificial DNA constructions has been increasing. So far, 3D DNA nanostructures are made from multiple DNA strands (oligonucleotides) with deliberately designed sequences. In this new study, Hao Yan of ASU, Yongli Mi of HKUST, and their colleagues have shown that DNA tetrahedrons can now be self-folded from only a single DNA strand. In addition, they demonstrated a method to replicate the DNA tetrahedrons in vivo, which could also be applied to the design and replication of other DNA nanostructures in the future.“A self-folded 3D nanocage that can be replicated in vivo tells us how powerful nature’s machineries are,” Yan and Mi told PhysOrg.com. “DNA nanostructures can serve as scaffolds to organize other material with controlled spatial arrangement. Spatial dependent biomolecular/nanomaterial interactions can thus be tuned and studied.”The DNA tetrahedrons, made of four triangular faces, were constructed from a DNA strand that was 286 nucleotides long. The tetrahedron’s six edges were composed of double helices: five were identical (double helical), while the sixth edge had a more complex “twin double-helical” structure. Four of the edges contained a cleavable site in the center, and all four vertices consisted of an unpaired thymine base to allow adequate flexibility for folding at these corners. Once the DNA strand was paired in this way, the researchers annealed the DNA in a process of heating and then cooling. When annealed, the DNA strand self-assembled into the seven-nanometer-long tetrahedron shape by combining the appropriate base pairs together. After confirming the successful assembly of the DNA tetrahedron, the researchers then developed a method to replicate the nanostructures using in vivo cloning in order to produce the nanostructures on a large scale. The researchers inserted one of the tetrahedrons into a cloning molecule called a phagemid, and then recovered several replicated tetrahedrons through a process of restriction digestion of the phagemid. This method is fully scalable, with the yield of cloned structures proportional to the size of the culture medium. As the researchers explain, using only a single DNA strand for creating nanostructures has several advantages, including simplifying the assembly process, increasing yield, offering the ability to scale up production, and creating structures with longer life spans in biological systems, such as inside living cells. This property is especially appealing for in vivo applications such as biosensing and drug delivery. In the future, the researchers hope to build on this method to synthesize nanostructures out of RNA, as well as build other complex shapes.More information: Zhe Li, Bryan Wei, Jeanette Nangreave, Chenxiang Lin, Yan Liu, Yongli Mi, and Hao Yan. “A Replicable Tetrahedral Nanostructure Self-Assembled from a Single DNA Strand.” J. Am. Chem. Soc. Doi: 10.1021/ja903768fCopyright 2009 PhysOrg.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com. Citation: Scientists Build Nanostructures out of Single DNA Strands (2009, September 8) retrieved 18 August 2019 from https://phys.org/news/2009-09-scientists-nanostructures-dna-strands.html Using living cells as nanotechnology factories
(PhysOrg.com) — While compact fluorescent lights (CFLs) are currently the primary alternative to incandescent light bulbs, a company from Seattle predicts that its own novel light bulbs will eventually replace CFLs and LEDs. Vu1 (“view one”) Corporation has been working on its electron stimulated luminescence (ESL) bulbs, and has recently released a demo video (below). On the other hand, LEDs don’t contain hazardous materials like mercury, and can last for up to 50,000 hours. However, their heat dissipation requirements make them more expensive than other bulbs, with a projected retail price of about $40 each.In contrast, ESLs don’t contain hazardous substances and should cost about $20, or the equivalent of a dimmable CFL reflector bulb, according to Vu1. Similar to CFLs, ESLs use 65% less energy than incandescent bulbs, and last for up to 6,000 hours, or about four times the lifespan of incandescents. Other advantages of ESLs include a warm color temperature similar to incandescent light, as well as the ability to be turned on instantly and be fully dimmable. Vu1 plans to begin manufacturing ESLs by the end of the year, and hopes to market the bulb starting in mid-2010. Initially, the company will launch reflector-shaped bulbs, which are used in recessed lighting. Later they hope to expand into other bulb forms such as standard A bulbs and tubes. More information: www.vu1.comvia: CNet Crave© 2009 PhysOrg.com Citation: Company Claims ESLs to be the Future of Light Bulbs (w/ Video) (2009, September 16) retrieved 18 August 2019 from https://phys.org/news/2009-09-company-esls-future-bulbs-video.html Explore further ‘Light within a light’ offers CFL efficiency with incandescent bulb shape ESL technology works by firing electrons at phosphor, which then glows. As Vu1 explains, the technology is similar to that used in cathode ray tubes and TVs. However, the bulbs have several improvements, such as in uniform electron distribution, energy efficiency, phosphor performance and manufacturing costs. “CRT and TV technology is based on delivering an electron ‘beam’ and then turning pixels on and off very quickly,” the company explains on its website. “ESL technology is based on uniformly delivering a ‘spray’ of electrons that illuminate a large surface very energy efficiently over a long lifetime.”With ESLs, Vu1 hopes to overcome some of the challenges faced by CFLs and LEDs, the two lighting technologies considered to have the most potential in the post-incandescent era. As the company explains, CFLs’ biggest problem is that they contain about 5 milligrams of mercury. If not recycled properly – or if they’re accidentally broken – CFLs release mercury into the air or groundwater. In addition, some people find the CFLs’ cooler colors less pleasing than the warmer tones of incandescent bulbs. Vu1’s conceptual design for its R-30 bulb. Credit: Vu1. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Copyright 2010 PhysOrg.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com. In a recent study, a team of researchers, Ronald Dreslinski, et al., from the University of Michigan, have investigated a solution to the power problem by using a method called near-threshold computing (NTC). In the NTC method, electronic devices operate at lower voltages than normal, which reduces energy consumption. The researchers predict that NTC could enable future computer systems to reduce energy requirements by 10 to 100 times or more, by optimizing them for low-voltage operation. Unfortunately, low-voltage operation also involves performance trade-offs: specifically, performance loss, performance variation, and memory and logic failures. Continuing Moore’s lawAs the researchers explain, reducing power consumption is essential for allowing the continuation of Moore’s law, which states that the number of transistors on a chip doubles about every two years. Continuing this exponential growth is becoming more and more difficult, and power consumption is the largest barrier to meaningful increases in chip density. While engineers can design chips to hold additional transistors, power consumption has begun to prohibit these devices from actually being used. As the researchers explain, engineers are currently facing “a curious design dilemma: more gates can now fit on a die, but a growing fraction cannot actually be used due to strict power limits. … It is not an exaggeration to state that developing energy-efficient solutions is critical to the survival of the semiconductor industry.” In the past, technologies that required large amounts of power eventually became replaced by more energy-efficient technologies; for example, vacuum tubes were replaced by transistors. Today, transistors are arranged using CMOS (complementary metal-oxide-semiconductor) circuitry design techniques. Since beyond-CMOS technologies are still far from being commercially viable, and large investments have been made in CMOS-based infrastructure, the Michigan researchers predict that CMOS will likely be around for a while. For this reason, solutions to the power problem must come from within. Using Moore’s law as the metric of progress has become misleading: starting around the 65-nm node, improvements in packing densities no longer translate to proportional increases in performance or energy efficiency. Researchers predict that near-threshold computing could restore the relationship between transistor density and energy efficiency. Credit: Dreslinski, et al. ©2010 IEEE. “NTC is an enabling technology that allows for continued scaling of CMOS-based devices, while significantly improving energy efficiency,” Dreslinski told PhysOrg.com. “The major impact of the work is that, for a fixed battery lifetime, significantly more transistors can be used, allowing for greater functionality. Particularly, [NTC allows] the full use of all transistors offered by technology scaling, eliminating ‘Dark Silicon’ that occurs as we scale to future technology nodes beyond 22 nm where ’more transistors can be placed on chip, but will be unable to be turned on concurrently.’”Operating at threshold voltageNear-threshold computing could be the key to decreasing power requirements without overturning the entire CMOS framework, the researchers say. Although low-voltage computing is already popular as an energy-efficient technique for ultralow-energy niche markets such as wristwatches and hearing aids, its large circuit delays lead to large energy leakages that have made it impractical for most computing segments. So far, these ultralow-energy devices have operated at extremely low “subthreshold” voltages, from around 200 millivolts down to the theoretical lower limit of 36 millivolts. Conventional voltage operation is about 1.0 volts. Meanwhile, near-threshold operation occurs around 400-500 millivolts, or near a device’s threshold voltage.Operating at near-threshold rather than subthreshold voltages could provide a compromise, enabling devices to require less energy while minimizing the energy leakage. This improved trade-off could potentially open up low-voltage design to mainstream semiconductor products. However, near-threshold computing still faces the other three challenges mentioned earlier: a 10 times performance loss, five times increase in performance variation, and an increase in functional failure rate of five orders of magnitude. These challenges have not been widely addressed so far, but the Michigan researchers spend the bulk of their analysis reviewing the current research to overcome these barriers.Part of the attraction of near-threshold computing is that it could have nearly universal applications in high-demand segments, such as data centers and personal computing. As the Web continues to grow, more data centers and servers are needed to host websites, and their power consumption is currently doubling about every five years. Personal computing devices, many of which are portable, could also benefit from increased battery lifetime due to reduced power needs. Dreslinski notes that previous studies have shown that the impact of NTC on devices will vary based on a particular consumer’s usage. “A user who only uses their device for making phone calls won’t see much impact because most of the power is consumed outside the CPU,” he said. “However, users who utilize music/video players and other compute-intensive tasks on their phone could see significant battery life improvements and reduced heat generated by the device. Quantifying these numbers is difficult based on the varying workloads of users coupled with parallel advances in battery technologies. My unofficial estimate would be a 1.5x to 2x improvement in battery lifetime, although some users could see significantly more or less.”Near-threshold computing could also be useful in sensor-based systems, which have applications in biomedical implants, among other areas. While these sensors may have a size of about 1 mm3, they often require batteries that are many orders of magnitude larger than the electronics themselves. By reducing the power requirements by up to 100 times in sensors, near-threshold computing could open the doors to many possible future designs. (PhysOrg.com) — While electronic devices have greatly improved in many regards, such as in storage capacity, graphics, and overall performance, etc., they still have a weight hanging around their neck: they’re huge energy hogs. When it comes to energy efficiency, today’s computers, cell phones, and other gadgets are little better off than those from a decade ago, or more. The problem of power goes beyond being green and saving money. For electrical engineers, power has become the primary design constraint for future electronic devices. Without lowering power consumption, improvements made in other areas of electronic devices could be useless, simply because there isn’t enough power to support them. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further Nanotech SRAM for battery devices unveiled Citation: Near-threshold computing could enable up to 100x reduction in power consumption (2010, February 17) retrieved 18 August 2019 from https://phys.org/news/2010-02-near-threshold-enable-100x-reduction-power.html More information: Ronald G. Dreslinski, Michael Wieckowski, David Blaauw, Dennis Sylvester, Trevor Mudge. “Near-Threshold Computing: Reclaiming Moore’s Law Through Energy Efficient Integrated Circuits.” Proceedings of the IEEE. Vol. 98, No. 2, February 2010. Doi:10.1109/JPROC2009.2034764
Dingo The dingo is considered a “pure” prehistoric dog, which was brought to Australia tens of thousands of years ago by the Aborigines. While they have in the past been associated with humans, they have adapted to surviving “wild” in the Australian outback. The dingo lies somewhere between the wolf, its ancient ancestor, and the domestic or pet dog, and has cognitive differences between the two. There has been little research done on dingoes, even though studies would aid in the understanding of the evolution of dogs, and it was unknown whether the dingo was more “wolf-like” or “dog-like”.Researchers in South Australia have now subjected the Australian dingo (Canis dingo) to the classic “detour task,” which has been used by previous researchers to assess the abilities of wolves (Canis lupus) and domestic dogs (Canis familiaris) to solve non-social, spatial problems. The detour task involves placing a treat behind a transparent or wire mesh fence. The dog can see the food but cannot get to it directly and has to find its way along the fence and through a door and then double back to get the food. Previous research has shown wolves are adept at solving the problem quickly, while domesticated dogs generally perform poorly and fail to improve significantly even after repeated trials. The wolves were also able to adapt easily when conditions were reversed, but pet dogs also generally fared poorly at this task.Until now dingoes had not been tested, so lead researcher, PhD student Mr. Bradley Smith of the School of Psychology at the University of South Australia, decided to subject 20 sanctuary-raised dingoes (Canis dingo) to the V-shaped detour task, in which a V-shaped fence is the barrier to the treat (a bowl of food) placed at the intersection point of the V, and the detour doors swung either inward or outward.The dingoes were randomly assigned to one of four experimental conditions previously used to test dogs and wolves. These were the inward or outward detour (with doors closed), inward detour (with doors open), and inward detour (with a human demonstrator). Each dingo was tested four times and then given a fifth trial with the conditions reversed.The results showed the dingoes completed the detour tasks successfully, and they achieved fewer errors and solved the problems more quickly (in around 20 seconds) than domestic dogs tested in previous research. Unlike domesticated dogs in previous studies, the dingoes did not look to humans for help, and only one dingo even looked at the human when solving the problem. This behavior was much more similar to findings with wolves than for pet dogs.The findings were published in the journal Animal Behaviour. All tests were carried out at the Dingo Discovery Centre in Victoria. (PhysOrg.com) — Studies in the past have shown that wolves are smarter than domesticated dogs when it comes to solving spatial problems, and now new research has shown that dingoes also solve the problems well. Citation: Dingoes, like wolves, are smarter than pet dogs (2010, June 11) retrieved 18 August 2019 from https://phys.org/news/2010-06-dingoes-wolves-smarter-pet-dogs.html © 2010 PhysOrg.com More information: References: — dx.doi.org/10.1016/j.anbehav.2010.04.017 — courses.media.mit.edu/2003spri … ciallearningdogs.pdf– dx.doi.org/10.1006/anbe.2001.1866 Study challenges popular image of dingo Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
The research team – Adelene Y. L. Sim in the Department of Applied Physics, and Prof. Michael Levitt and Dr. Peter Minary in the Department of Structural Biology – faced a range of challenges in devising their unique algorithm. Speaking with PhysOrg, Minary and Sim describe those challenges. “Reducing dimensionality may eliminate physically relevant paths connecting conformational basins and therefore introducing artificial energy barriers that do not present obstacles in Cartesian space,” Minary tells PhysOrg. “In the present case, the major challenge was to develop an algorithm that supports degrees of freedom representing arbitrary collective rearrangements at all-atom resolution.”Unfortunately, Minary notes, using these degrees of freedom, or DOFs, could break chain connectivity – and the corresponding conformational space is likely to be associated with extremely rough energy surface topology. “To overcome these limitations,” he adds, “less collective rearrangements need to be utilized only at a necessary extent so that rearrangements along the more collective DOFs are optimally facilitated without significantly increasing the volume of the sampled conformational space.” In short, their major challenge was implementing a universal algorithm capable of exploring conformational space while allowing numerous sets of arbitrary and/or user-defined so-called natural DOFs.The team addressed these issues, Minary says, by building on the preexisting high-level computational environment of the MOSAICS software package that enabled the use of arbitrary even chain breaking DOFs. “To further improve on this concept,” he adds, “a very flexible new interface had to be invented that welcomes users to define their own system specific DOFs. In addition, the interface also had to support the weighted superposition of arbitrary DOFs. Finally a universal algorithm that realizes the interaction of various sets of DOFs needed to be implemented.” By so doing, conformational paths along the most collective molecular rearrangements are augmented by the incorporation of progressively more detailed molecular flexibility without significantly altering the dimensionality problem, which is better quantified by the conformational volume to be sampled rather than the actual number of DOFs. Effects of adding hierarchical degrees of freedom on sampling a large symmetric RNA structure. (A) Hierarchical moves used. A system of this complexity has many possible collective motions. Here seven sets of independent degrees of freedom (L1 to L7) are defined. (B) Convergence is accelerated by higher order rigid body moves. When nested hierarchical moves L1 to L7 were used, rapid convergence to the limiting is reached within 2 × 104 iterations (vertical dashed line labeled *). Image Copyright © PNAS, doi: 10.1073/pnas.1119918109 Other innovations are also in the works. “In the current paper we showed that our algorithm satisfies some necessary conditions of phase space, or detailed balance, preserving sampling not satisfied by any of the available algorithms used to model RNA systems,” Minary notes. “Further efforts are invested to fully satisfy microscopic reversibility.” Moreover, computational efficiency may be improved by using information on the collective nature of DOFs when updating atomic interactions, or by defining energy functional forms in terms of low dimensional analytical coordinates. Minary points out that sampling efficiency could also be improved if the current approach is combined with some advanced sampling algorithms based on multi-canonical sampling available in MOSAICS.In addition, he continues, the movement of explicit water could be incorporated into the hierarchical moves so that effects of solvation can be more accurately evaluated – and testing the method with various implicit solvent representations may also be informative. “Finally,” he says, “we’re planning to introduce a more user friendly – possibly graphical – interface that would bridge the gap between algorithm developers and computational biologists, physicists and chemists who have great insight and intuitions about the natural DOFs of various molecular assemblies and complexes.” Altogether, all the above efforts, which would increase mathematical rigor, computational speed, solvent details and accessibility to users, could further extend the boundaries of applications beyond the current systems being considered.In the meantime, while developing all the necessary algorithms discussed above, the team plans to continue extending the range of target applications. “Besides modeling the structure of chromatin,” Minary illustrates, “we’d like to revisit questions in DNA nanotechnology.” Furthermore, the use of a refinement method other than Cryo-EM (Cryo-Electron Microscopy, a form of transmission electron microscopy where samples are studied at cryogenic temperatures, and which the team is already pursuing) is also planned. “We intend to extend our work to extensively explore RNA junction flexibility,” adds Sim, “and are also currently looking into using our technique in RNA structure prediction of large RNA systems.” In terms of applications, Sim continues, “in medicine it’s vital to understand the flexibility, stability, shape and possible distortions of nanostructures to better evaluate the nanostructure quality. These properties could play crucial roles in dictating cellular internalization and/or toxicity of nanostructures.”Sim points out that with their efficient modeling tool, although still dependent on the quality of the force field used, the team is now more capable of studying these properties in silico. “Additionally,” Sim notes, “we’re looking into optimization in sequence- and structure-space simultaneously by having sequence as an additional degree of freedom.” A possible application is the sequence design of silencing RNA, or siRNA.Looking further afield, Minary tells PhysOrg, there are other technologies and applications that might benefit from their findings. “Since proper sampling and exploration of the conformational space is a basic tool used in various technologies and applications, the method could be used in design, homology modeling and various new applications such as modeling collective rearrangements in trans-membrane proteins, designing new nucleic acid nanostructures, modeling large protein-nucleic acid assemblies, such a the ribosome, and the in silico study of chromatin remodeling. In addition,” he adds, “we’d like to aid the refinement and interpretation of experimental techniques.” Specifically, building on former efforts to refine Cryo-EM data, they’d like to develop tools to analyze NMR, FRET, SAXS, X-Ray, and footprinting experiments in order to generate conformational ensembles that satisfy experimental constraints. Finally, Minary points out that the algorithm they developed is very general in nature and could be also utilized in other disciplines that involve state spaces with a large number of variables that are changing in a correlated manner. “In particular,” he concludes, “the basic idea could be used but not limited to sampling the space of possible networks, as in systems biology applications, or stock market variables.” More information: Modeling and design by hierarchical natural moves, PNAS February 21, 2012 vol. 109 no. 8 2890-2895, doi: 10.1073/pnas.1119918109Related:The effects of polymeric nanostructure shape on drug delivery, Advanced Drug Delivery Reviews, Volume 63, Issues 14–15, November 2011, Pages 1228–1246, doi: 10.1016/j.addr.2011.06.016 Square-Shaped RNA Particles from Different RNA Folds, Nano Letters, February 24, 2009 (Web), 9 (3), 1270–1277, doi: 10.1021/nl900261h Citation: Modeling the miniscule: High-resolution design of nanoscale biomolecules (2012, March 12) retrieved 18 August 2019 from https://phys.org/news/2012-03-miniscule-high-resolution-nanoscale-biomolecules.html Explore further Swimming upstream: Flux flow reverses for lattice bosons in a magnetic field This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. (PhysOrg.com) — A key element of both biotechnology and nanotechnology is – perhaps unsurprisingly – computational modeling. Frequently, in silico nanostructure design and simulation precedes actual experimentation. Moreover, the ability to use modeling to predict biomolecular structure lays the foundation for the subsequent design of biomolecules. Historically, the problem has been that most modeling software presents a tradeoff between being general purpose (in being able to model systems at high/atomic resolution) but limited in scope (i.e., only explores a small fraction conformational space around the initial structure). Recently, however, Stanford University scientists have developed an algorithm – implemented in a modeling program known as MOSAICS (Methodologies for Optimization and SAmpling In Computational Studies) – that achieves nanoscale modeling at the resolution required without being limited by the scope/size dilemma. In addition, the researchers successfully modeled – and benchmarked the new computation modeling technique with – RNA-based nanostructures. Copyright 2012 PhysOrg.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com.
Citation: E-mail use model appears to follow “Clash of Civilizations” prediction (2013, March 8) retrieved 18 August 2019 from https://phys.org/news/2013-03-e-mail-clash-civilizations.html (Phys.org) —Researchers at Stanford University have built a model based on the frequency of e-mail interactions between groups of users of Yahoo! e-mail throughout the world. In studying their results, they have found, as they report in their paper they’ve uploaded to the preprint server arXiv, it appears to adhere to societal boundaries as described by Samuel Huntington’s 1992 book “The Clash of Civilizations.” The Mesh of Civilizations. Source: Yahoo! email dataset. Rescaled densities. Only top 1,000 densities displayed. Credit: arxiv.org/abs/1303.0045 Journal information: arXiv Yahoo tries to entice users with e-mail facelift More information: The Mesh of Civilizations and International Email Flows, arXiv:1303.0045 [cs.SI] arxiv.org/abs/1303.0045AbstractIn The Clash of Civilizations, Samuel Huntington argued that the primary axis of global conflict was no longer ideological or economic but cultural and religious, and that this division would characterize the “battle lines of the future.” In contrast to the “top down” approach in previous research focused on the relations among nation states, we focused on the flows of interpersonal communication as a bottom-up view of international alignments. To that end, we mapped the locations of the world’s countries in global email networks to see if we could detect cultural fault lines. Using IP-geolocation on a worldwide anonymized dataset obtained from a large Internet company, we constructed a global email network. In computing email flows we employ a novel rescaling procedure to account for differences due to uneven adoption of a particular Internet service across the world. Our analysis shows that email flows are consistent with Huntington’s thesis. In addition to location in Huntington’s “civilizations,” our results also attest to the importance of both cultural and economic factors in the patterning of inter-country communication ties.via Arxiv Blog This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2013 Phys.org Huntington famously suggested in his book that future wars would revolve around cultural and religious differences and even offered a list of groups of people in them: Sinic, Hindu, Islamic, Latin American, Western, Orthodox, African and Buddhist.The researchers at Stanford, led by Bogdan State, didn’t set out to create a model that would reflect Huntington’s vision, but instead found it came about on its own after the data was compiled and graphed. Their model is based on over ten million e-mail messages sent from Yahoo! users the world over. To show the degree of interaction between groups, the team used nodes and lines between them—the more transactions between groups, the closer they appear together on the model. They also carefully note that only Yahoo! users that agreed to have their data used in the study were included. To form geographic areas, the team compared IP numbers attached to messages with the location noted in a user’s profile, using only those that coincided.The resulting color-coded graphic model offers near instant visual clues regarding groups bound together by culture and perhaps religion. Perhaps more importantly it also shows boundaries, which State and his team claim, resemble the model first proposed by Huntington. Western nodes are clustered to form a single group with just a few outliers, for example, as are others such as those deemed Islamic, or South American.The model doesn’t hint at tensions between groups of course, but does seem to indicate that groups tend to communicate more via e-mail with others in their same group than they do with others from other groups, even if they share a physical border. Other patterns that show up indicate what would seem natural—that people who speak the same language tend to send more e-mails to each other than to people who don’t. People in Great Britain for example, appear to send more e-mails to people in Australia than to people in other, much closer, European countries. Explore further
Citation: Amphibious fish found to use evaporative cooling to overcome hot water (2015, October 21) retrieved 18 August 2019 from https://phys.org/news/2015-10-amphibious-fish-evaporative-cooling-hot.html Mangrove rivulus. Credit: Wikipedia There are many varieties of amphibious fish—those fish that jump or crawl out of the water to hang out on land for awhile, but until now, no one has seen an example of one that jumps out of the water to use evaporative cooling to chill its body after swimming in water that was too hot. Prior research had shown that mangrove rivulus jump (or more accurately flip themselves out of the water by bending then releasing quickly) but it was not clear why they did so—other amphibious fish have been known to get out of the water if CO2 build up, or if there were pollutants, or even to snag a meal, but that did not seem to apply to the mangrove rivulus.To find out more about the fish (which look sort of like tadpoles) the researchers raised some specimens for a year in tanks in their lab, at a temperature of 25 or 30°C and also collected wild adults and put them in tanks in their lab too, and acclimated them for a time at the same temperature as those they had raised. Then, they watched and filmed (with a thermal imaging camera) what happened as the temperature of the water was raised. The fish, as expected hurled themselves out of the tank onto “shore”—when the temperature reached approximately 36°C. The researchers also enclosed the fish tanks so that they could create different levels of humidity and found that the fish cooled better in lower humidity environments. They also found that despite high humidity, the fish could all cool themselves down to ambient temperature within minutes. In studying the fish, the researchers found that not only was it able to use evaporative cooling, but its behavior also demonstrated plasticity, because it was dependent on recent acclimation history rather than conditioning when they were young. This suggests the fish is remarkably well suited to handling warmer waters as the planet heats up. More information: Out of the frying pan into the air—emersion behaviour and evaporative heat loss in an amphibious mangrove fish (Kryptolebias marmoratus), Biology Letters, Published 21 October 2015.DOI: 10.1098/rsbl.2015.0689 AbstractAmphibious fishes often emerse (leave water) when faced with unfavourable water conditions. How amphibious fishes cope with the risks of rising water temperatures may depend, in part, on the plasticity of behavioural mechanisms such as emersion thresholds. We hypothesized that the emersion threshold is reversibly plastic and thus dependent on recent acclimation history rather than on conditions during early development. Kryptolebias marmoratus were reared for 1 year at 25 or 30°C and acclimated as adults (one week) to either 25 or 30°C before exposure to an acute increase in water temperature. The emersion threshold temperature and acute thermal tolerance were significantly increased in adult fish acclimated to 30°C, but rearing temperature had no significant effect. Using a thermal imaging camera, we also showed that emersed fish in a low humidity aerial environment (30°C) lost significantly more heat (3.3°C min−1) than those in a high humidity environment (1.6°C min−1). In the field, mean relative humidity was 84%. These results provide evidence of behavioural avoidance of high temperatures and the first quantification of evaporative cooling in an amphibious fish. Furthermore, the avoidance response was reversibly plastic, flexibility that may be important for tropical amphibious fishes under increasing pressures from climatic change.Press release This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Journal information: Biology Letters (Phys.org)—A team of researchers affiliated with the University of Guelph and Brock University, both in Canada, has found the first example of an amphibious fish using evaporative cooling to chill its overheated body. In their paper published in the journal Biology Letters, the researchers describe their study that included raising Kryptolebias marmoratus, aka mangrove rivulus, to adulthood and then testing them by heating the water in which they lived. © 2015 Phys.org Explore further Flipping fish adapt to land living (w/ Video)
Designer Aneeth Arora’s collection Pero Spring 2014 is on display at Moon River in the Capital. The collection consists of an exclusive array of ethereal whites with vintage beading. Arora’s particular brand of anti-fit, frumpy chic clothing is a hardsell in India, where the average person won’t understand the concept of paying four figures for a mulmul shirt. However, her understanding of delicate textiles and persistent effort in elevating their status has earned her fans among international buyers and won her Vogue India’s first-ever Fashion Fund Award. All of which combined has turned her into a hot ticket on the Indian fashion circuit.Alhough Arora is not one to experiment with silhouettes or colours, this collection offered far more variety than her usual efforts. Her dainty slip dresses are ephemeral, but her collection also includes androgynous pant suits, decked out in hot pink gingham checks. Even saris made it to the final cut, polka dotted and worn with soft jackets instead of the traditional choli blouse.
Lending support to the Government’s efforts to promote cleanliness, GAIL (India) Limited has adopted two historical monuments in Delhi- Purana Quila and Safdarjung Tomb – for upkeep and sanitation purposes as part of the Swachh Bharat Abhiyaan. It is a part of GAILS’s corporate social responsibility. Swachh Bharat Abhiyaan is a national level campaign by the Government of India, covering 4041 statutory towns to clean the streets, roads and infrastructure of the country GAIL employees have also been regularly participating in cleanliness drives in and around the company’s corporate office at Bhikaiji Cama Place for atleast two hours every week since the commencement of the Swachh Bharat Abhiyaan. Also Read – ‘Playing Jojo was emotionally exhausting’Activities such as cleaning of office peripheral areas, roads, railway stations, government schools, beaches, villages, delivering lectures to school going children on health tips, sensitizing contract personnel regarding importance of hygiene, etc. are being carried out at GAIL work sites across the country. In addition to this, GAIL (India) Limited has taken over the work of constructing over 1,000 toilets in schools across the country in a significant move towards fulfilling the PM’s commitment towards providing hygienic sanitation facilities for girl students. GAIL (India) Limited is the largest state-owned natural gas processing and distribution company in India.
The study divided 62 individuals with diagnosed clinical depression into three groups, in which two participated in two different types of exercise with a physiotherapist twice a week for 10 weeks while the third, the control group, did not participate in systematic exercise.”In our follow-up interviews for the study, participants spoke about how they felt alive again and became more active. One woman expressed… the workout ‘kickstarts my body and helps me get the strength to crawl out of this cocoon that I am in’,” said
KOLKATA: The Kolkata Municipal Corporation (KMC) has issued showcause notice to a senior official, on charges of dereliction of duty.Though there has not been heavy rainfall in Kolkata, several streets, roads and lanes in the Kidderpore-Mominpur area are still under water. Local people have urged civic authorities to take immediate steps and sought the intervention of Chief Minister Mamata Banerjee.Tarak Singh, Member, Mayor-in-Council (Drainage), along with municipal commissioner Khalil Ahmed and other senior officials of the Drainage department, went to Mominpur pumping station and talked to the officials about the delay in clearing the accumulated water. Senior KMC officials found that Sanjay Mondol, assistant engineer of the pumping station, had not taken appropriate steps to clear the water. He has been issued a showcause notice. Also Read – Heavy rain hits traffic, flightsSingh assured that water from the affected areas will be cleared by Thursday morning. He reiterated that the KMC is ready to face monsoon. Even if it rains heavily, some streets in the city will be flooded but the duration of waterlogging will be less than the previous years. It had rained heavily from Monday night and some streets got waterlogged. But the accumulated water from the streets, including the low lying areas of Bhowanipore, Kalighat and Chetla, got cleared by Tuesday evening. Singh said all the 35 heavy duty pumps installed in KMC’s pumping stations, are functioning.
In a bid to improve infrastructural development in the national Capital, the Delhi Assembly on Friday passed a private member bill to bring Delhi Development Authority (DDA) under the control of the Delhi government, amid claims that the land-owning agency has no free land for infrastructural development. AAP MLA Sanjiv Jha moved a resolution in the Assembly seeking DDA to come under the Delhi government. Moving the proposal on Friday, Jha said: “The DDA has failed to execute the master plan and it is responsible for the condition of the unauthorised colonies. If Delhi government needs land, it has to place a request before the DDA.” Also Read – Company director arrested for swindling Rs 345 croreHe alleged that corruption in DDA has casted a shadow on regularisation of unauthorised colonies.“DDA’s land pooling policy doesn’t say how it will do land pooling in unauthorised colonies,” the AAP lawmaker said.Another AAP MLA, Dinesh Mohaniya told the Delhi Assembly that the elected government in Delhi has
Taparia on Tuesday launched a new product naming it Steel File. While launching the new
Kolkata: One of the three Romanians, who was arrested in Chandigarh, is found to be involved in the ATM fraud case that took place in Kolkata.It may be recalled that Chandigarh police had arrested three persons including one 37-year-old Miclea Lecian Lonut a few days ago in connection with a separate ATM fraud case.Officers of the Special Investigation Team (SIT) that was formed to probe into the incident received information about the arrest of the three persons. Later, they found that one of them is also involved in the ATM fraud cases that took place in Kolkata. Also Read – Rain batters Kolkata, cripples normal lifeA team comprising police officers of the SIT has left for Chandigarh in this connection. It may be recalled that details of several bank account holders were collected by installing skimming machines at different ATM counters across the city.They used to prepare cloned cards using the collected details, which were later used to withdraw cash from ATMs in Delhi.Sources said the investigating officers found his photographs while going through footages of the CCTVs installed at the ATMs in Delhi. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedHe was found withdrawing cash from an ATM in Delhi and the investigating officers suspect that he had withdrawn money using a cloned card.The police are now going to record his statement in this connection. They would try to know about his connection with those arrested in Kolkata in connection with the ATM fraud. It is suspected that they are from the same gang and operate in small groups in different parts of the country. Cops are trying to find out about the counterparts in other parts of the country. Meanwhile, four persons have been arrested in connection with a case in which they used to replace new expensive mobile phones with cheaper ones before delivering them to actual owners.A 25-year-old youth, Subho Acharya, who is a resident of Shyampukur, and Mahesh Kumar Hela (23), a resident of Gariahat, were arrested with two others in this connection.They used work in a goods delivery company. Investigation revealed that they used to replace the original expensive mobile phones from sealed packets with cheaper ones.A few days ago, a complaint was lodged with Kasba police station in this connection by the company where the duo worked. It was alleged that their activity led to a loss of Rs 2,76,080 for the company.
Do you forward a chain mail even though you know fully well that your action would not bring any promised luck? This is because you might consider the costs of ignoring rationality is low relative to the costs of ignoring intuition, suggests new research.The researchers found that detecting an irrational thought and correcting that error are two separate processes, not one as most dual-system cognitive models assume. This insight explains how people can detect irrational thought and choose not to correct it, a process described as ‘acquiescence’ in the study. Also Read – ‘Playing Jojo was emotionally exhausting’“Even when the conditions are all perfect for detecting an error, when people have the ability and motivation to be rational and when the context draws attention to the error, the magical intuition may still prevail,” said researcher Jane Risen from University of Chicago Booth School of Business in the US.Understanding how acquiescence unfolds in magical thinking, can help provide insight into how it is that people knowingly behave irrationally in many other areas of life, the study said. Also Read – Leslie doing new comedy special with NetflixCertain variables create situations in which intuition is likely to override rational thought. For example, people may acquiesce if they can rationalise their intuition by thinking that a particular situation is special. Acquiescence may also be more likely if the costs of ignoring rationality are low relative to the costs of ignoring intuition, the researchers said.The findings will be published in an upcoming issue of the journal Psychological Review.
79 youth in Kashmir Valley have joined various terror outfits during this year, a figure which is 30 per cent higher than that of the previous year, Rajya Sabha was informed on Wednesday.Replying to a written question by BJP member Lal Sinh Vadodia, Minister of State for Home Haribhai Parathibhai Chaudhary said as per reports, 79 youths have joined militant ranks during 2015 (as on November 30) whereas 60 youths joined militant ranks during the corresponding period of 2014.There has been a growing concern within the security establishment about the sudden increase in disappearance of youths in Kashmir Valley this year and reports coming in suggest that they have joined various militant organisations, especially pro-Pakistan Hizbul Mujahideen led by Burhan Wani.The minister informed the Upper House that the terrorist activities in the Jammu and Kashmir were regularly being monitored and reviewed at various levels. He said that the government has adopted various counter measures to neutralise these efforts and capabilities of militants to disturb peace in the state.Chaudhary said the government has also encouraged policies to mainstream the youth, including providing employment opportunities to wean them away from militancy.He said various steps have been initiated, including proactively taking suitable measures to safeguard the borders from cross-border terrorism and containing militancy.
Kolkata: As many as 22 passengers were injured some of them critically when a bus they were travelling in overturned on Berhapore-Hariharpara Road on Wednesday morning.All the injured persons were taken to Murshidabad Medical College and Hospital by the local people immediately after the incident. The local people took part in the rescue operation before the police reached the spot. Police said that a private bus on its way to Berhampore with 35 passengers overturned near Katabagan area under Berhampore police station at around 10 am. The local people heard a loud thud and rushed to the spot. They brought the injured persons out of the bus many of whom were in traumatised condition. Some of the victims had received serious head injuries. Also Read – Bose & Gandhi: More similar than apart, says Sugata BoseThe eyewitnesses told the police that the driver was over-speeding the vehicle. The bus driver applied sudden brake when it overturned. The exact cause of the accident is yet to be confirmed by the police. The incident caused traffic congestion in the area for sometime. The police later removed the vehicle from the place and the traffic movement was restored. The police are investigating if the bus developed any technical snag resulting in the accident. The bus driver reportedly injured in the accident. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataAccording to the police, around seven passengers are stated to be in critical condition. According to the preliminary investigation police suspect that the bus driver might have applied the emergency brake as biker might have come on its way. The bus was also seriously damaged in the accident. Police also suspect that bus was running at an average speed between 50-60 when the accident occurred. Police have started a detailed probe in this connection.
Darjeeling: The Darjeeling Terai Dooars Plantation Labour Union (DTDPLU, affiliated to the Gorkha Janmukti Morcha) will stop the dispatch of tea from Hill tea gardens from Thursday. The Joint Forum of Tea Unions will stop the plucking of leaves in the tea gardens from March 11. The move comes in protest against the non-payment of arrears in around 60 percent tea gardens in the Hills.This is the time of the premium first flush tea, which is exported. “In January 2018, the daily wages of tea garden workers had been increased by Rs 17.50. However, in most of the gardens in the Hills, the increment took effect from March 2018. A year has passed and the arrears have still not been paid,” stated Balam Tamang, president, Darjeeling sub-division committee, DTDPLU. Also Read – Bose & Gandhi: More similar than apart, says Sugata BoseTamang stated that upon hearing about the blockade of tea dispatch, the Darjeeling Tea Association has called for a meeting of the management of the gardens that have not paid the arrears and trade union representatives on Friday. “We will stop tea dispatches from Thursday. Depending on the outcome of the meeting on March 8, we will decide on our future course of action,” stated Tamang. The Joint Forum (conglomeration of 6 unions) has launched a dharna at the Darjeeling Tea Association. “We will hold gate meetings from Thursday till March 9. If arrears are not paid by March 10, we will stop the plucking of tea leaves from March 11,” stated J B Tamang, convener of the forum. It may be mentioned that there are 87 tea gardens in the Darjeeling Hills.